Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence
Date
2008
Authors
Strauss O.J.
Warren R.M.
Jordaan A.
Streicher E.M.
Hanekom M.
Falmer A.A.
Albert H.
Trollip A.
Hoosain E.
Van Helden P.D.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Description
Keywords
rifampicin, tuberculostatic agent, antibiotic resistance, article, bacterial strain, bacterial transmission, bacterium isolation, bacterium mutant, controlled study, gene mutation, Human immunodeficiency virus infection, in vitro study, mixed infection, morbidity, Mycobacterium tuberculosis, nonhuman, pathogenesis, phenotype, prevalence, priority journal, single nucleotide polymorphism, sputum analysis, tuberculosis, classification, codon, disease transmission, drug effect, genetics, genotype, human, Human immunodeficiency virus 1, microbiological examination, microbiology, mutation, South Africa, virology, Human immunodeficiency virus, Mycobacterium tuberculosis, Antibiotics, Antitubercular, Codon, Drug Resistance, Bacterial, Genotype, HIV Infections, HIV-1, Humans, Microbial Sensitivity Tests, Mutation, Mycobacterium tuberculosis, Polymorphism, Single Nucleotide, Prevalence, Rifampin, South Africa, Tuberculosis, Multidrug-Resistant
Citation
Journal of Clinical Microbiology
46
4
46
4