• No evidence of HIV replication in children on antiretroviral therapy 

  Van Zyl, Gert U.; Katusiime, Mary Grace; Wiegand, Ann; McManus, William R.; Bale, Michael J.; Halvas, Elias K.; Luke, Brian; Boltz, Valerie F.; Spindler, Jonathan; Laughton, Barbara; Engelbrecht, Susan; Coffin, John M.; Cotton, Mark F.; Shao, Wei; Mellors, John W.; Kearney, Mary F. (American Society for Clinical Investigation, 2017)

  It remains controversial whether current antiretroviral therapy (ART) fully suppresses the cycles of HIV replication and viral evolution in vivo. If replication persists in sanctuary sites such as the lymph nodes, a high ...
  
  
• Measuring thiols in single cultivar South African red wines using 4,4-dithiodipyridine (DTDP) derivatization and ultraperformance convergence chromatography-tandem mass spectrometry 

  Mafata, Mpho; Stander, Maria A.; Thomachot, Baptiste; Buica, Astrid (MDPI, 2018)

  Wine varietal thiols are important contributors to wine aroma. The chemical nature of thiols makes them difficult to measure due to low concentrations, high sensitivity to oxidation, and low ionization. Methods for the ...
  
  
• The effect of extensive human presence at an early age on stress responses and reactivity of juvenile ostriches towards humans 

  Muvhali, Pfunzo T.; Bonato, Maud; Engelbrecht, Anel; Malecki, Irek A.; Hough, Denise; Robinson, Jane E.; Evans, Neil P.; Cloete, Schalk W. P. (MDPI, 2018-07)

  The effect of extensive human presence and regular gentle handling performed at an early age (0–3 months old) on stress responses and reactivity of juvenile ostriches towards humans was investigated. A total of 416 ostrich ...
  
  
• The impact of plasticizer and degree of hydrolysis on free volume of poly(vinyl alcohol) films 

  Fong, Rebecca J.; Robertson, Alexander; Mallon, Peter E.; Thompson, Richard L. (MDPI, 2018-05)

  The effect of plasticizer species and the degree of hydrolysis (DH) on the free volume properties of poly(vinyl alcohol) (PVA) were studied using positron annihilation lifetime spectroscopy. Both glycerol and propylene ...
  
  
• Foliar application of steinernema yirgalemense to control planococcus ficus : assessing adjuvants to improve efficacy 

  Platt, T.; Stokwe, N. F.; Malan, A. P. (South African Society for Enology and Viticulture, 2018)

  The vine mealybug (Planococcus ficus) is regarded as a key mealybug pest of grapevines in South Africa, with entomopathogenic nematodes (EPNs) being touted as a potential alternative to chemical control, although their ...
  
  
• The perceptions of students and lecturers on the live streaming of lectures as an alternative to attending class 

  Rossouw, M. (HESA, 2018)

  Rising student numbers and unpredictable unrest situations on campuses in South Africa have begged for alternatives to (or substitutes for) physical class attendance to address these problems. This study aimed to test ...
  
  
• Students’ and lecturers’ perceptions of the effect of open-book examinations on teaching and assessment at departments of accountancy at South African universities 

  Kruger, S. J. (HESA, 2018)

  Strong arguments are put forward in literature that teaching methods should be aligned with assessment practices in order to optimise the teaching-learning environment. The decision by the South African Institute of Chartered ...
  
  
• What is (post)quanlitative research? 

  Le Grange, L. (HESA, 2018)

  The (post)human turn has ushered in new ways of doing inquiry. (Post)humanism is the catalyst for news ways of thinking and doing research under an umbrella term called (post)qualitative research. In this article I discuss ...
  
  
• Academics at three African universities on the perceived utilisation of their research 

  Boshoff, N.; Esterhuyse, H.; Wachira-Mbui, D. N.; Owoaje, E. T.; Nyandwi, T.; Mutarindwa, S. (HESA, 2018)

  his article contributes to emerging knowledge on the utilisation of university research in sub-Saharan Africa. A survey was conducted comprising 463 academics at three African universities: the University of Ibadan (Nigeria), ...
  
  
• Growth at the microscale : long term thinning effects on patterns and timing of intra-annual stem increment in radiata pine 

  Drew, David M.; Downes, Geoffrey M. (SpringerOpen, 2018-10-09)

  Background: Stem radial growth in forests is not uniform. Rather, it is characterized by periods of relatively fast or slow growth, or sometimes no growth at all. These fluctuations are generally a function of varying ...
  
  
• Advancing global health through cardiovascular research, mentorship, and capacity building : in memoriam, professor Bongani Mayosi (1967–2018) 

  Nachega, Jean B.; Ntsekhe, Mpiko; Volmink, Jimmy; Thabane, Lehana (BMC (part of Springer Nature), 2018-10-03)

  No abstract
  
  
• Feasibility, acceptability and potential sustainability of a ‘diagonal’ approach to health services for female sex workers in Mozambique 

  Lafort, Yves; Ismael de Melo, Malica S.; Lessitala, Faustino; Griffin, Sally; Chersich, Matthew; Delva, Wim (BMC (part of Springer Nature), 2018-10-03)

  Background: Female sex workers (FSWs) in many settings have restricted access to sexual and reproductive health (SRH) services. We therefore conducted an implementation study to test a ‘diagonal’ intervention which ...
  
  
• Comparative cardio and developmental toxicity induced by the popular medicinal extract of Sutherlandia frutescens (L.) R.Br. detected using a zebrafish Tuebingen embryo model 

  Chen, Longsheng; Xu, Minjie; Gong, Zhunan; Zonyane, Samkele; Xu, Shuwen; Makunga, Nokwanda P. (BMC (part of Springer Nature), 2018-10-05)

  Background: Sutherlandia frutescens is one of the most promising commercialized, indigenous and medicinal plants of South Africa that is used as an immune-booster, and a traditional treatment for cancer. However, few studies ...
  
  
• A Lanosteryl triterpene from Protorhus longifolia augments insulin signaling in type 1 diabetic rats 

  Ephraim, Mabhida Sihle; Rabia, Johnson; Musawenkosi, Ndlovu; Felicia, Sangweni Nonhlakanipho; Johan, Louw; Andrew, Opoku; Anthony, Mosa Rebamang (BMC (part of Springer Nature), 2018-10-01)

  Background: A substantial literature supports antidiabetic properties of the lanosteryl triterpene (methyl-3β- hydroxylanosta-9,24-dien-21-oate, RA-3) isolated from Protorhus longifolia stem bark. However, the ...
  
  
• Thymic Output and CD4 T-Cell Reconstitution in HIV-Infected Children on Early and Interrupted Antiretroviral Treatment: Evidence from the Children with HIV Early Antiretroviral Therapy Trial 

  Lewis, Joanna; Payne, Helen; Walker, A. Sarah; Otwombe, Kennedy; Gibb, Diana M.; Babiker, Abdel G.; Panchia, Ravindre; Cotton, Mark. F.; Violari, Avy; Klein, Nigel; Callard, Robin E. (2017-09)

  Objectives: Early treatment of HIV-infected children and adults is important for optimal immune reconstitution. Infants’ immune systems are more plastic and dynamic than older children’s or adults’, and deserve particular ...
  
  
• The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing 

  Nieuwenhuizen, Natalie E.; Kulkarni, Prasad S.; Shaligram, Umesh; Cotton, Mark F.; Rentsch, Cyrill A.; Eisele, Bernd; Grode, Leander; Kaufmann, Stefan H. E. (2017-09)

  The only licensed vaccine against tuberculosis (TB), bacille Calmette–Guérin (BCG), protects against severe extrapulmonary forms of TB but is virtually ineffective against the most prevalent form of the disease, pulmonary ...
  
  
• Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency 

  Schlechter, Nikola; Glanzmann, Brigitte; Hoal, Eileen Garner; Schoeman, Mardelle; Petersen, Britt-Sabina; Franke, Andre; Lau, Yu-Lung; Urban, Michael; Van Helden, Paul David; Esser, Maria Esser; Moller, Marlo; Kinnear, Craig (2017-11)

  Primary immunodeficiency disorders (PIDs) render patients vulnerable to infection with a wide range of microorganisms and thus provide good in vivo models for the assessment of immune responses during infectious challenges. ...
  
  
• A review : the fate of bacteriocins in the human gastro-intestinal tract : do they cross the gut–blood barrier? 

  Dicks, Leon M. T.; Dreyer, Leane; Smith, Carine; Van Staden, Anton D. (Frontiers Media, 2018)

  The intestinal barrier, consisting of the vascular endothelium, epithelial cell lining, and mucus layer, covers a surface of about 400 m2. The integrity of the gut wall is sustained by transcellular proteins forming tight ...
  
  
• The Kinetics of the Humoral and Interferon-Gamma Immune Responses to Experimental Mycobacterium bovis Infection in the White Rhinoceros (Ceratotherium simum) 

  Parsons, Sven D. C.; Morar-Leather, Darshana; Buss, Peter; Hofmeyr, Jennifer; McFadyen, Ross; Rutten, Victor P. M. G.; Van Helden, Paul D.; Miller, Michele A.; Michel, Anita Luise (2017-12)

  Mycobacterium bovis is the cause of tuberculosis (TB) in a wide range of species, including white rhinoceroses (Ceratotherium simum). Control of the disease relies on the indirect detection of infection by measuring ...
  
  
• Plant functional trait data and reflectance spectra for 22 palmiet wetland species 

  Rebelo, Alanna J.; Somers, Ben; Esler, Karen J.; Meire, Patrick (Elsevier, 2018)

  We provide reflectance spectra for 22 South African palmiet wetland species collected in spring 2015 from three wetlands throughout the Cape Floristic Region. In addition, we provide summarized plant functional trait data, ...
  
  
• TBVAC2020: Advancing Tuberculosis Vaccines from Discovery to Clinical Development 

  Kaufmann, Stefan H. E.; Dockrell, Hazel M.; Drager, Nick; Ho, Mei Mei; McShane, Helen; Neyrolles, Olivier; Ottenhoff, Tom H. M.; Patel, Brij; Roordink, Danielle; Spertini, Francois; Stenger, Steffen; Thole, Jelle; Verreck, Frank A. W.; Williams, Ann; Consortium, TBVAC2020 (2017-10)

  TBVAC2020 is a research project supported by the Horizon 2020 program of the European Commission (EC). It aims at the discovery and development of novel tuberculosis (TB) vaccines from preclinical research projects to early ...
  
  
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  A cross sectional survey to evaluate knowledge, attitudes and practices regarding seasonal influenza and influenza vaccination among diabetics in Pretoria, South Africa 

  Olatunbosun, Olawale D.; Esterhuizen, Tonya M.; Wiysonge, Charles S. (Elsevier, 2017-11-07)

  Background: In South Africa, influenza vaccination is recommended to all diabetics. However, vaccinationcoverage among diabetics remains low. Therefore, this study aimed to explore the knowledge, attitudes,and practices ...
  
  
• 

  Anti-Group B Streptococcus antibody in infants born to mothers with human immunodeficiency virus (HIV) infection 

  Le Doare, Kirsty; Allen, Lauren; Kampmann, Beate; Heath, Paul Trafford; Taylor, Stephen; Hesseling, Anneke C.; Gorringe, Andrew; Jones, Christine Elizabeth (Elsevier, 2015-01-29)

  Background: HIV-exposed uninfected infants have increased infection risk and mortality compared to HIV-unexposed infants. HIV-exposed infants may be at increased risk of invasive GBS disease due to reduced maternal antibody ...
  
  
• 

  Using rodent models to simulate stress of physiologically relevant severity : when, why and how 

  Smith, Carine (InTech, Rijeka, Croatia, 2012)

  Given the demands of modern life, it is no wonder that the concept of stress has become a household topic for discussion. Also in the academic realm the phenomenon which is stress, is topping the charts in terms of ...
  
  
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  Chemoprevention of LA7-induced mammary tumor growth by SM6Met, a well-characterized cyclopia extract 

  Oyenihi, Omolola R.; Krygsman, Annadie; Verhoog, Nicolette; De Beer, Dalene; Saayman, Michael J.; Mouton, Thys M.; Louw, Ann (Frontiers, 2018)

  Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a wellcharacterized extract of Cyclopia subternata with reported ...
  
  
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  Novel role for receptor dimerization in post-translational processing and turnover of the GRα 

  Louw, Ann; Wilkinson, Legh; Verhoog, Nicolette (Nature, 2018)

  Glucocorticoids (GCs), acting via the glucocorticoid receptor (GRα), remain the mainstay therapeutic choice for the treatment of inflammation. However, chronic GC use, aside from generating undesirable side-effects, ...
  
  
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  The role of bile acids in nutritional support 

  Van Niekerk, Gustav; Davis, Tanja; De Villiers, Willem; Engelbrecht, Anna-Mart (BioMed Central, 2018-09-30)

  Abstract: Nutritional support continues to receive much attention as a possible intervention to prevent loss of lean tissue mass, promote recovery and re-establish proper immune function in critical care patients. Yet there ...
  
  
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  Building capacity in primary care rehabilitation clinical practice guidelines : a South African initiative 

  Louw, Q.; Grimmer, K.; Dizon, J. M; Machingaidze, S.; Parker, H.; Ernstzen, D. (BioMed Central, 2018-09-29)

  Background: The large number of South Africans with disability who cannot access good quality rehabilitation presents a public health and human rights challenge. A cost-effective, efficient approach is required to address ...
  
  
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  Impact of alcohol consumption on tuberculosis treatment outcomes : a prospective longitudinal cohort study protocol 

  Myers, Bronwyn; Bouton, Tara C.; Ragan, Elizabeth J.; White, Laura F.; McIlleron, Helen; Theron, Danie; Parry, Charles D. H.; Horsburgh, C. R.; Warren, Robin M.; Jacobson, Karen R. (BioMed Central, 2018-09-29)

  Background: An estimated 10% of tuberculosis (TB) deaths are attributable to problematic alcohol use globally, however the causal pathways through which problem alcohol use has an impact on TB treatment outcome is not ...
  
  
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  Customer interaction with controlled retail mix elements and their relationships with customer loyalty in diverse retail environments 

  Terblanche, N. S. (Academy of Business and Retail Management, 2017)

  Customer loyalty as an outcome holds various advantages for a retailer. It is therefore important that a retailer provides the type and level of retail mix elements for interaction that customers’ desire and which results ...
  
  

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