Spread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence

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dc.contributor.authorStrauss O.J.
dc.contributor.authorWarren R.M.
dc.contributor.authorJordaan A.
dc.contributor.authorStreicher E.M.
dc.contributor.authorHanekom M.
dc.contributor.authorFalmer A.A.
dc.contributor.authorAlbert H.
dc.contributor.authorTrollip A.
dc.contributor.authorHoosain E.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorVictor T.C.
dc.date.accessioned2011-05-15T15:56:54Z
dc.date.available2011-05-15T15:56:54Z
dc.date.issued2008
dc.description.abstractThe fitness cost associated with the evolution of resistance to rifampin in Mycobacterium tuberculosis may be different in clinical isolates compared to in vitro-generated mutants. An atypical Beijing strain (attenuated phenotype) demonstrated the ability to spread despite acquiring resistance to rifampin. Transmission was linked to human immunodeficiency virus coinfection (P = 0.029), raising concern for the spread of drug resistance in vulnerable populations. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Clinical Microbiology
dc.identifier.citation46
dc.identifier.citation4
dc.identifier.issn951137
dc.identifier.other10.1128/JCM.01938-07
dc.identifier.urihttp://hdl.handle.net/10019.1/10108
dc.subjectrifampicin
dc.subjecttuberculostatic agent
dc.subjectantibiotic resistance
dc.subjectarticle
dc.subjectbacterial strain
dc.subjectbacterial transmission
dc.subjectbacterium isolation
dc.subjectbacterium mutant
dc.subjectcontrolled study
dc.subjectgene mutation
dc.subjectHuman immunodeficiency virus infection
dc.subjectin vitro study
dc.subjectmixed infection
dc.subjectmorbidity
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectphenotype
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectsingle nucleotide polymorphism
dc.subjectsputum analysis
dc.subjecttuberculosis
dc.subjectclassification
dc.subjectcodon
dc.subjectdisease transmission
dc.subjectdrug effect
dc.subjectgenetics
dc.subjectgenotype
dc.subjecthuman
dc.subjectHuman immunodeficiency virus 1
dc.subjectmicrobiological examination
dc.subjectmicrobiology
dc.subjectmutation
dc.subjectSouth Africa
dc.subjectvirology
dc.subjectHuman immunodeficiency virus
dc.subjectMycobacterium tuberculosis
dc.subjectAntibiotics, Antitubercular
dc.subjectCodon
dc.subjectDrug Resistance, Bacterial
dc.subjectGenotype
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectMicrobial Sensitivity Tests
dc.subjectMutation
dc.subjectMycobacterium tuberculosis
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPrevalence
dc.subjectRifampin
dc.subjectSouth Africa
dc.subjectTuberculosis, Multidrug-Resistant
dc.titleSpread of a low-fitness drug-resistant Mycobacterium tuberculosis strain in a setting of high human immunodeficiency virus prevalence
dc.typeArticle
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