Visualizing the dynamics of tuberculosis pathology using molecular imaging
Date
2021-03
Journal Title
Journal ISSN
Volume Title
Publisher
American Society for Clinical Investigation
Abstract
Nearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a
deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood
disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu
(bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change
independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes.
Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D
spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology
could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel
diagnostics, biomarkers, and therapeutics.
Description
CITATION: Ordonez, A. A. et al. 2021. Visualizing the dynamics of tuberculosis pathology using molecular imaging. J Clin Invest. 2021;131(5):e145107. doi.10.1172/JCI145107
The original publication is available at: jci.org
The original publication is available at: jci.org
Keywords
Mycobacterium tuberculosis -- Pathogenesis, Tuberculosis -- Alternative treatment, Diagnostic imaging, UCTD
Citation
CITATION: Ordonez, A. A. et al. 2021. Visualizing the dynamics of tuberculosis pathology using molecular imaging. J Clin Invest. 2021;131(5):e145107. doi.10.1172/JCI145107