Visualizing the dynamics of tuberculosis pathology using molecular imaging

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dc.contributor.authorOrdonez, Alvaro A.en_ZA
dc.contributor.authorTucker, Elizabeth W.en_Za
dc.contributor.authorAnderson, Carolyn J.en_ZA
dc.contributor.authorCarter, Claire L.en_ZA
dc.contributor.authorGanatra, Shashanken_ZA
dc.contributor.authorKaushal, Deepaken_ZA
dc.contributor.authorKramnik, Igoren_ZA
dc.contributor.authorLin, Philana L.en_ZA
dc.contributor.authorMadigan, Cressida A.en_ZA
dc.contributor.authorMendez, Susanaen_ZA
dc.contributor.authorRao, Jianghongen_ZA
dc.contributor.authorSavic, Rada M.en_ZA
dc.contributor.authorTobin, David M.en_ZA
dc.contributor.authorWalzl, Gerharden_ZA
dc.contributor.authorWilkinson, Robert J.en_ZA
dc.contributor.authorLacourciere, Karen A.en_ZA
dc.contributor.authorVia, Laura E.en_ZA
dc.contributor.authorJain, Sanjay K.en_ZA
dc.date.accessioned2023-03-27T08:13:27Zen_ZA
dc.date.available2023-03-27T08:13:27Zen_ZA
dc.date.issued2021-03en_ZA
dc.descriptionCITATION: Ordonez, A. A. et al. 2021. Visualizing the dynamics of tuberculosis pathology using molecular imaging. J Clin Invest. 2021;131(5):e145107. doi.10.1172/JCI145107en_ZA
dc.descriptionThe original publication is available at: jci.orgen_ZA
dc.description.abstractNearly 140 years after Robert Koch discovered Mycobacterium tuberculosis, tuberculosis (TB) remains a global threat and a deadly human pathogen. M. tuberculosis is notable for complex host-pathogen interactions that lead to poorly understood disease states ranging from latent infection to active disease. Additionally, multiple pathologies with a distinct local milieu (bacterial burden, antibiotic exposure, and host response) can coexist simultaneously within the same subject and change independently over time. Current tools cannot optimally measure these distinct pathologies or the spatiotemporal changes. Next-generation molecular imaging affords unparalleled opportunities to visualize infection by providing holistic, 3D spatial characterization and noninvasive, temporal monitoring within the same subject. This rapidly evolving technology could powerfully augment TB research by advancing fundamental knowledge and accelerating the development of novel diagnostics, biomarkers, and therapeutics.en_ZA
dc.description.versionPublisher’s versionen_ZA
dc.format.extent12 pagesen_ZA
dc.identifier.citationCITATION: Ordonez, A. A. et al. 2021. Visualizing the dynamics of tuberculosis pathology using molecular imaging. J Clin Invest. 2021;131(5):e145107. doi.10.1172/JCI145107en_ZA
dc.identifier.issn0021-9738 (print)en_ZA
dc.identifier.issn1558-8238 (online)en_ZA
dc.identifier.otherdoi.10.1172/JCI145107en_ZA
dc.identifier.urihttp://hdl.handle.net/10019.1/126717en_ZA
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society for Clinical Investigationen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectMycobacterium tuberculosis -- Pathogenesisen_ZA
dc.subjectTuberculosis -- Alternative treatmenten_ZA
dc.subjectDiagnostic imagingen_ZA
dc.subjectUCTDen_ZA
dc.titleVisualizing the dynamics of tuberculosis pathology using molecular imagingen_ZA
dc.typeArticleen_ZA
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