Effect of HIV infection status and Anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants

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dc.contributor.authorMadhi S.A.
dc.contributor.authorAdrian P.
dc.contributor.authorCotton M.F.
dc.contributor.authorMcIntyre J.A.
dc.contributor.authorJean-Philippe P.
dc.contributor.authorMeadows S.
dc.contributor.authorNachman S.
dc.contributor.authorKayhty H.
dc.contributor.authorKlugman K.P.
dc.contributor.authorViolari A.
dc.date.accessioned2011-05-15T16:03:32Z
dc.date.available2011-05-15T16:03:32Z
dc.date.issued2010
dc.description.abstractSerotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4+ cell percentages ≥25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART+ group). Immune responses were also evaluated in HIV-noninfected infants born to HIV-seronegative (M+/I+) or HIV-positive mothers (M+/I+). Antibody concentrations were similar between HIV+/ART+ and HIV+/ART+ infants. However, antibody concentrations were lowerin M+/I+ infants than in M+/I+ infants. Nevertheless, M+/I+ infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART+ infants. © 2010 by the Infectious Diseases Society of America.
dc.description.versionArticle
dc.identifier.citationJournal of Infectious Diseases
dc.identifier.citation202
dc.identifier.citation3
dc.identifier.issn221899
dc.identifier.other10.1086/653704
dc.identifier.urihttp://hdl.handle.net/10019.1/12668
dc.subjectantibody
dc.subjectantiretrovirus agent
dc.subjectCD4 antigen
dc.subjectlamivudine
dc.subjectlopinavir
dc.subjectPneumococcus vaccine
dc.subjectritonavir
dc.subjectzidovudine
dc.subjectanti human immunodeficiency virus agent
dc.subjectbacterium antibody
dc.subjectheptavalent pneumococcal conjugate vaccine
dc.subjectopsonin
dc.subjectantibody blood level
dc.subjectantibody response
dc.subjectarticle
dc.subjectbacterial pneumonia
dc.subjectCD4 lymphocyte count
dc.subjectclinical trial
dc.subjectconjugate
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectHuman immunodeficiency virus
dc.subjectHuman immunodeficiency virus infected patient
dc.subjectHuman immunodeficiency virus infection
dc.subjectimmune response
dc.subjectimmunogenicity
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmulticenter study
dc.subjectnewborn
dc.subjectopsonophagocytic activity
dc.subjectphagocytosis
dc.subjectpriority journal
dc.subjectqualitative analysis
dc.subjectquantitative analysis
dc.subjectrandomized controlled trial
dc.subjectserotype
dc.subjectStreptococcus pneumoniae
dc.subjectadult
dc.subjectblood
dc.subjectimmunology
dc.subjectpregnancy
dc.subjectpregnancy complication
dc.subjectAdult
dc.subjectAnti-HIV Agents
dc.subjectAntibodies, Bacterial
dc.subjectCD4 Lymphocyte Count
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHumans
dc.subjectInfant
dc.subjectMale
dc.subjectOpsonin Proteins
dc.subjectPhagocytosis
dc.subjectPneumococcal Vaccines
dc.subjectPregnancy
dc.subjectPregnancy Complications, Infectious
dc.subjectYoung Adult
dc.titleEffect of HIV infection status and Anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants
dc.typeArticle
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