Effect of HIV infection status and Anti-retroviral treatment on quantitative and qualitative antibody responses to pneumococcal conjugate vaccine in infants
Date
2010
Authors
Madhi S.A.
Adrian P.
Cotton M.F.
McIntyre J.A.
Jean-Philippe P.
Meadows S.
Nachman S.
Kayhty H.
Klugman K.P.
Violari A.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Serotype-specific antibody concentration and opsonophagocytic activity (OPA) were evaluated after 3 doses of pneumococcal conjugate vaccine. Groups included human immunodeficiency virus (HIV)-positive infants with CD4+ cell percentages ≥25% who initiated immediate antiretroviral treatment (the HIV+/ART+ group) or whose antiretroviral treatment was deferred until clinically or immunologically indicated (the HIV+/ART+ group). Immune responses were also evaluated in HIV-noninfected infants born to HIV-seronegative (M+/I+) or HIV-positive mothers (M+/I+). Antibody concentrations were similar between HIV+/ART+ and HIV+/ART+ infants. However, antibody concentrations were lowerin M+/I+ infants than in M+/I+ infants. Nevertheless, M+/I+ infants had superior OPA responses, compared with those in HIV+/ART+ infants, who in turn had better OPA responses, compared with those in HIV+/ART+ infants. © 2010 by the Infectious Diseases Society of America.
Description
Keywords
antibody, antiretrovirus agent, CD4 antigen, lamivudine, lopinavir, Pneumococcus vaccine, ritonavir, zidovudine, anti human immunodeficiency virus agent, bacterium antibody, heptavalent pneumococcal conjugate vaccine, opsonin, antibody blood level, antibody response, article, bacterial pneumonia, CD4 lymphocyte count, clinical trial, conjugate, controlled clinical trial, controlled study, female, highly active antiretroviral therapy, human, Human immunodeficiency virus, Human immunodeficiency virus infected patient, Human immunodeficiency virus infection, immune response, immunogenicity, infant, major clinical study, male, multicenter study, newborn, opsonophagocytic activity, phagocytosis, priority journal, qualitative analysis, quantitative analysis, randomized controlled trial, serotype, Streptococcus pneumoniae, adult, blood, immunology, pregnancy, pregnancy complication, Adult, Anti-HIV Agents, Antibodies, Bacterial, CD4 Lymphocyte Count, Female, HIV Infections, Humans, Infant, Male, Opsonin Proteins, Phagocytosis, Pneumococcal Vaccines, Pregnancy, Pregnancy Complications, Infectious, Young Adult
Citation
Journal of Infectious Diseases
202
3
202
3