Distinct serum biosignatures are associated with different tuberculosis treatment outcomes
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
ENGLISH ABSTRACT: Biomarkers for TB treatment response and outcome are needed. This study characterize changes in immune profiles during TB treatment, define biosignatures associated with treatment outcomes, and explore the feasibility of predictive models for relapse. Seventy-two markers were measured by multiplex cytokine array in serum samples from 78 cured, 12 relapsed and 15 failed treatment patients from South Africa before and during therapy for pulmonary TB. Promising biosignatures were evaluated in a second cohort from Uganda/Brazil consisting of 17 relapse and 23 cured patients. Thirty markers changed significantly with different response patterns during TB treatment in cured patients. The serum biosignature distinguished cured from relapse patients and a combination of two clinical (time to positivity in liquid culture and BMI) and four immunological parameters (TNF-β, sIL-6R, IL-12p40 and IP-10) at diagnosis predicted relapse with a 75% sensitivity (95%CI 0.38–1) and 85% specificity (95%CI 0.75–0.93). This biosignature was validated in an independent Uganda/Brazil cohort correctly classifying relapse patients with 83% (95%CI 0.58–1) sensitivity and 61% (95%CI 0.39–0.83) specificity. A characteristic biosignature with value as predictor of TB relapse was identified. The repeatability and robustness of these biomarkers require further validation in well-characterized cohorts.
Description
CITATION: Walzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859.
CITATION: Walzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859.
The original publication is available at http://journals.tubitak.gov.tr
CITATION: Walzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859.
The original publication is available at http://journals.tubitak.gov.tr
Keywords
Tuberculosis, Biochemical markers, Tuberculosis -- Complications, Tuberculosis -- Treatment, Tuberculosis -- Relapse
Citation
Walzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859