Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

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dc.contributor.advisorWalzla, Gerharden_ZA
dc.contributor.authorRonachera, Katharinaen_ZA
dc.contributor.authorChegoua, Novel N.en_ZA
dc.contributor.authorKleynhansa, Leanieen_ZA
dc.contributor.authorSiawayac, Joel F. Djobaen_ZA
dc.contributor.authorDu Plessis, Nelitaen_ZA
dc.contributor.authorLoxton, Andre G.en_ZA
dc.contributor.authorMaasdorp, Eliznaen_ZA
dc.contributor.authorTromp, Gerarden_ZA
dc.contributor.authorKidd, Martinen_ZA
dc.contributor.authorStanleya, Kimen_ZA
dc.contributor.authorKriela, Magdalenaen_ZA
dc.contributor.authorMenezesa, Angelaen_ZA
dc.contributor.authorGutschmidta, Andreaen_ZA
dc.contributor.authorVan Der Spuya, Gian D.en_ZA
dc.contributor.authorWarrena, Robin M.en_ZA
dc.contributor.authorDietzee, Reynaldoen_ZA
dc.contributor.authorOkweraf, Alphonseen_ZA
dc.contributor.authorThielg, Bonnieen_ZA
dc.contributor.authorBelisleh, John T.en_ZA
dc.contributor.authorCliffi, Jacqueline M.en_ZA
dc.contributor.authorBoomg, W. Henryen_ZA
dc.contributor.authorJohnsong, John L.en_ZA
dc.contributor.authorVan Heldena, Paul D.en_ZA
dc.contributor.authorDockrelli, Hazel M.en_ZA
dc.date.accessioned2021-01-27T16:24:43Z
dc.date.available2021-01-27T16:24:43Z
dc.date.issued2019
dc.descriptionCITATION: Walzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859.
dc.descriptionCITATION: Walzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859.
dc.descriptionThe original publication is available at http://journals.tubitak.gov.tr
dc.description.abstractENGLISH ABSTRACT: Biomarkers for TB treatment response and outcome are needed. This study characterize changes in immune profiles during TB treatment, define biosignatures associated with treatment outcomes, and explore the feasibility of predictive models for relapse. Seventy-two markers were measured by multiplex cytokine array in serum samples from 78 cured, 12 relapsed and 15 failed treatment patients from South Africa before and during therapy for pulmonary TB. Promising biosignatures were evaluated in a second cohort from Uganda/Brazil consisting of 17 relapse and 23 cured patients. Thirty markers changed significantly with different response patterns during TB treatment in cured patients. The serum biosignature distinguished cured from relapse patients and a combination of two clinical (time to positivity in liquid culture and BMI) and four immunological parameters (TNF-β, sIL-6R, IL-12p40 and IP-10) at diagnosis predicted relapse with a 75% sensitivity (95%CI 0.38–1) and 85% specificity (95%CI 0.75–0.93). This biosignature was validated in an independent Uganda/Brazil cohort correctly classifying relapse patients with 83% (95%CI 0.58–1) sensitivity and 61% (95%CI 0.39–0.83) specificity. A characteristic biosignature with value as predictor of TB relapse was identified. The repeatability and robustness of these biomarkers require further validation in well-characterized cohorts.en_ZA
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S1472979219302276?via%3Dihub#!
dc.description.versionPublisher's version
dc.format.extent8 pagesen_ZA
dc.identifier.citationWalzla, G., et al. 2019. Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis,118:101859, doi:10.1016/j.tube.2019.101859
dc.identifier.issn1472-9792 (print)
dc.identifier.otherdoi:10.1016/j.tube.2019.101859
dc.identifier.urihttp://hdl.handle.net/10019.1/109029
dc.language.isoen_ZAen_ZA
dc.publisherElsevier
dc.rights.holderAuthors retain copyright
dc.subjectTuberculosisen_ZA
dc.subjectBiochemical markersen_ZA
dc.subjectTuberculosis -- Complicationsen_ZA
dc.subjectTuberculosis -- Treatmenten_ZA
dc.subjectTuberculosis -- Relapseen_ZA
dc.titleDistinct serum biosignatures are associated with different tuberculosis treatment outcomesen_ZA
dc.typeArticleen_ZA
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