Ataxia telangiectasia mutated protein kinase : a potential master puppeteer of oxidative stress-induced metabolic recycling
Date
2021
Journal Title
Journal ISSN
Volume Title
Publisher
Hindawi
Abstract
ENGLISH ABSTRACT: Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis. Best known for its role as a transducer of DNA damage repair, the activity of ATM in the cytosol is enjoying increasing attention, where it plays a central role in general cellular recycling (macroautophagy) as well as the targeted clearance (selective autophagy) of damaged mitochondria and peroxisomes in response to oxidative stress, independently of the DNA damage response. The importance of ATM activation by oxidative stress has also recently been highlighted in the clearance of protein aggregates, where the expression of a functional ATM construct that cannot be activated by oxidative stress resulted in widespread accumulation of protein aggregates. This review will discuss the role of ATM in general autophagy, mitophagy, and pexophagy as well as aggrephagy and crosstalk between oxidative stress as an activator of ATM and its potential role as a master regulator of these processes.
Description
The original publication is available at https://bmcpediatr.biomedcentral.com
Publication of this article was funded by the Stellenbosch University Open Access Fund
Publication of this article was funded by the Stellenbosch University Open Access Fund
Keywords
Ataxia telangiectasia -- Mutation (Biology), Protein kinases, Oxidation, Physiological
Citation
Blignaut, M., et al. 2021. Ataxia telangiectasia mutated protein kinase : a potential master puppeteer of oxidative stress-induced metabolic recycling. Oxidative Medicine and Cellular Longevity, 2021, Article ID 8850708, doi:10.1155/2021/8850708