Ataxia telangiectasia mutated protein kinase : a potential master puppeteer of oxidative stress-induced metabolic recycling
| dc.contributor.author | Blignaut, Marguerite | en_ZA |
| dc.contributor.author | Harries, Sarah | en_ZA |
| dc.contributor.author | Lochner, Amanda | en_ZA |
| dc.contributor.author | Huisamen, Barbara | en_ZA |
| dc.date.accessioned | 2021-04-19T12:49:00Z | |
| dc.date.available | 2021-04-19T12:49:00Z | |
| dc.date.issued | 2021 | |
| dc.description | The original publication is available at https://bmcpediatr.biomedcentral.com | |
| dc.description | Publication of this article was funded by the Stellenbosch University Open Access Fund | |
| dc.description.abstract | ENGLISH ABSTRACT: Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis. Best known for its role as a transducer of DNA damage repair, the activity of ATM in the cytosol is enjoying increasing attention, where it plays a central role in general cellular recycling (macroautophagy) as well as the targeted clearance (selective autophagy) of damaged mitochondria and peroxisomes in response to oxidative stress, independently of the DNA damage response. The importance of ATM activation by oxidative stress has also recently been highlighted in the clearance of protein aggregates, where the expression of a functional ATM construct that cannot be activated by oxidative stress resulted in widespread accumulation of protein aggregates. This review will discuss the role of ATM in general autophagy, mitophagy, and pexophagy as well as aggrephagy and crosstalk between oxidative stress as an activator of ATM and its potential role as a master regulator of these processes. | en_ZA |
| dc.description.uri | https://www.hindawi.com/journals/omcl/2021/8850708/ | |
| dc.description.version | Publisher's version | |
| dc.format.extent | 12 pages | en_ZA |
| dc.identifier.citation | Blignaut, M., et al. 2021. Ataxia telangiectasia mutated protein kinase : a potential master puppeteer of oxidative stress-induced metabolic recycling. Oxidative Medicine and Cellular Longevity, 2021, Article ID 8850708, doi:10.1155/2021/8850708 | |
| dc.identifier.issn | 1942-0994 (online) | |
| dc.identifier.issn | 1942-0900 (print) | |
| dc.identifier.other | doi:10.1155/2021/8850708 | |
| dc.identifier.uri | http://hdl.handle.net/10019.1/109780 | |
| dc.language.iso | en_ZA | en_ZA |
| dc.publisher | Hindawi | en_ZA |
| dc.rights.holder | Authors retain copyright | E |
| dc.subject | Ataxia telangiectasia -- Mutation (Biology) | en_ZA |
| dc.subject | Protein kinases | en_ZA |
| dc.subject | Oxidation, Physiological | en_ZA |
| dc.title | Ataxia telangiectasia mutated protein kinase : a potential master puppeteer of oxidative stress-induced metabolic recycling | en_ZA |
| dc.type | Article | en_ZA |