Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life
Date
2012-09-13
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
The first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination
strategies.
Description
CITATION: Reikie, B. A., et al. 2012. Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS ONE, 7(9): 1-11, doi: 10.1371/journal.pone.0044763.
The original publication is available at http://journals.plos.org/plosone
The original publication is available at http://journals.plos.org/plosone
Keywords
Toll-Like Receptors, Infants -- Development -- South Africa, Cytokines, Natural immunity, Ontogeny, Infection in infants -- South Africa, Vaccination of infants -- Sub-Saharan Africa
Citation
Reikie, B. A., et al. 2012. Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS ONE, 7(9): 1-11, doi:10.1371/journal.pone.0044763