Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life

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dc.contributor.authorReikie, Brian A.en_ZA
dc.contributor.authorAdams, Rozanne C. M.en_ZA
dc.contributor.authorRuck, Candice E.en_ZA
dc.contributor.authorHo, Kevinen_ZA
dc.contributor.authorLeligdowicz, Aleksandraen_ZA
dc.contributor.authorPillay, Santoshanen_ZA
dc.contributor.authorNaidoo, Shalenaen_ZA
dc.contributor.authorFortuno III, Edgardo S.en_ZA
dc.contributor.authorDe Beer, Corenaen_ZA
dc.contributor.authorPreiser, Wolfgangen_ZA
dc.contributor.authorCotton, Mark F.en_ZA
dc.contributor.authorSpeert, David P.en_ZA
dc.contributor.authorEsser, Monikaen_ZA
dc.contributor.authorKollmann, Tobias R.en_ZA
dc.date.accessioned2013-03-01T06:37:09Z
dc.date.available2013-03-01T06:37:09Z
dc.date.issued2012-09-13
dc.descriptionCITATION: Reikie, B. A., et al. 2012. Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS ONE, 7(9): 1-11, doi: 10.1371/journal.pone.0044763.
dc.descriptionThe original publication is available at http://journals.plos.org/plosone
dc.description.abstractThe first year of life represents a time of marked susceptibility to infections; this is particularly true for regions in sub-Saharan Africa. As innate immunity directs the adaptive immune response, the observed increased risk for infection as well as a suboptimal response to vaccination in early life may be due to less effective innate immune function. In this study, we followed a longitudinal cohort of infants born and raised in South Africa over the first year of life, employing the most comprehensive analysis of innate immune response to stimulation published to date. Our findings reveal rapid changes in innate immune development over the first year of life. This is the first report depicting dramatic differences in innate immune ontogeny between different populations in the world, with important implications for global vaccination strategies.en_ZA
dc.description.sponsorshipThis work was in part supported by National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH); Grant number: N01 AI50023, British Columbia Children’s Hospital Foundation, The Martha Piper Fund, and the Peter Wall Institute for Advanced Studies. TRK is supported in part by a Career Award in the Biomedical Sciences from the Burroughs Wellcome Fund, and by a Candian Institute of Health Research (CIHR) Training Grant in Canadian Child Health Clinician Scientist Program, in partnership with SickKids Foundation, Child & Family Research Institute (BC), Women & Children’s Health Research Institute (Alberta), Manitoba Institute of Child Health. BAR is supported in full by the Michael Smith Foundation for Health Research (ST-SGS-02657(09-1)CLIN). ALS is supported by a CIHR Canada-HOPE Scholarship. DPS in the Sauder Family Professor of Pediatric Infectious Diseases. Laboratory analyses in South Africa were funded through National Health Laboratory Service Research Trust, Grant number TY94171; National Health Laboratory Service, K Fund numbers KNC97 and KNC103; Poliomyelitis Research Foundation, Short Term Research Grant number 10/02; and Harry Crossley Foundation, numbers 5415 and 5762. Student bursaries were awarded by Poliomyelitis Research Foundation, numbers 10/31 and 11/37. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_ZA
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044763
dc.description.versionPublisher's versionen_ZA
dc.format.extent11 pages
dc.identifier.citationReikie, B. A., et al. 2012. Ontogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS ONE, 7(9): 1-11, doi:10.1371/journal.pone.0044763
dc.identifier.issn1932-6203 (online)
dc.identifier.issn1932-6203 (print)
dc.identifier.otherdoi: 10.1371/journal.pone.0044763
dc.identifier.urihttp://hdl.handle.net/10019.1/79622
dc.language.isoen_ZAen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectToll-Like Receptorsen_ZA
dc.subjectInfants -- Development -- South Africaen_ZA
dc.subjectCytokinesen_ZA
dc.subjectNatural immunityen_ZA
dc.subjectOntogenyen_ZA
dc.subjectInfection in infants -- South Africaen_ZA
dc.subjectVaccination of infants -- Sub-Saharan Africaen_ZA
dc.titleOntogeny of toll-like receptor mediated cytokine responses of South African infants throughout the first year of lifeen_ZA
dc.typeArticleen_ZA
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