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Molecular epidemiological interpretation of the epidemic of extensively drug-resistant tuberculosis in South Africa
Streicher, Elizabeth M. ; Sampson, S. L. ; Dheda, K. ; Dolby, T. ; Simpson, J. A. ; Victor, T. C. ; Gey van Pittius, Nicolaas C. ; Van Helden, Paul D. ; Warren, Robin M. (2015)
CITATION: Streicher, E. M. et al. 2015. Molecular epidemiological interpretation of the epidemic of extensively drug-resistant Tuberculosis in South Africa. Journal of Clinical Microbiology, 53:3650 –3653, doi:10.1128/JCM.01414-15.
The original publication is available at http://jcm.asm.org
We show that the interpretation of molecular epidemiological data for extensively drug-resistant tuberculosis (XDR-TB) is dependent on the number of different markers used to define transmission. Using spoligotyping, IS6110 DNA fingerprinting, and DNA sequence data, we show that XDR-TB in South Africa (2006 to 2008) was predominantly driven by the acquisition of second-line drug resistance.