Molecular epidemiological interpretation of the epidemic of extensively drug-resistant tuberculosis in South Africa

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dc.contributor.authorStreicher, Elizabeth M.en_ZA
dc.contributor.authorSampson, S. L.en_ZA
dc.contributor.authorDheda, K.en_ZA
dc.contributor.authorDolby, T.en_ZA
dc.contributor.authorSimpson, J. A.en_ZA
dc.contributor.authorVictor, T. C.en_ZA
dc.contributor.authorGey van Pittius, Nicolaas C.en_ZA
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorWarren, Robin M.en_ZA
dc.date.accessioned2016-10-06T07:39:26Z
dc.date.available2016-10-06T07:39:26Z
dc.date.issued2015
dc.descriptionCITATION: Streicher, E. M. et al. 2015. Molecular epidemiological interpretation of the epidemic of extensively drug-resistant Tuberculosis in South Africa. Journal of Clinical Microbiology, 53:3650 –3653, doi:10.1128/JCM.01414-15.
dc.descriptionThe original publication is available at http://jcm.asm.org
dc.description.abstractWe show that the interpretation of molecular epidemiological data for extensively drug-resistant tuberculosis (XDR-TB) is dependent on the number of different markers used to define transmission. Using spoligotyping, IS6110 DNA fingerprinting, and DNA sequence data, we show that XDR-TB in South Africa (2006 to 2008) was predominantly driven by the acquisition of second-line drug resistance.en_ZA
dc.description.urihttp://jcm.asm.org/content/53/11/3650.abstract?sid=87ccabc5-55ba-4da7-8ef0-0b2779b9da61
dc.description.versionPublisher's version
dc.format.extent4 pages
dc.identifier.citationStreicher, E. M. et al. 2015. Molecular epidemiological interpretation of the epidemic of extensively drug-resistant Tuberculosis in South Africa. Journal of Clinical Microbiology, 53:3650 –3653, doi:10.1128/JCM.01414-15.
dc.identifier.issn1098-660X (online)
dc.identifier.issn0095-1137 (print)
dc.identifier.otherdoi:10.1128/JCM.01414-15
dc.identifier.urihttp://hdl.handle.net/10019.1/99700
dc.language.isoen_ZAen_ZA
dc.publisherAmerican Society for Microbiology
dc.rights.holderAmerican Society for Microbiology
dc.subjectExtensively Drug-Resistant Tuberculosis -- Genetic aspectsen_ZA
dc.subjectMolecular epidemiologyen_ZA
dc.subjectSpoligotypingen_ZA
dc.subjectDrug resistant tuberculosis -- Genetic aspectsen_ZA
dc.titleMolecular epidemiological interpretation of the epidemic of extensively drug-resistant tuberculosis in South Africaen_ZA
dc.typeArticleen_ZA
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