Doctoral Degrees (Physiological Sciences)
Recent Submissions
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Metabolic reprograming and cancer resistance : an investigation into the metabolic control of cancer-associated fibroblasts on breast cancer cell survival and metastasis
(Stellenbosch : Stellenbosch University, 2018-03)ENGLISH ABSTRACT: Introduction: Cancer-associated fibroblasts (CAFs) constitute the most abundant mesenchymal cell type present within the tumour microenvironment. Recent evidence suggests that nutrient deprived cancer ... -
An investigation into the potential cardioprotective effects of ghrelin in a rat model of chronic Doxorubicin-induced cardiotoxicity
(Stellenbosch : Stellenbosch University, 2017-12)ENGLISH SUMMARY: Introduction Doxorubicin (DOX) is an anthracycline that has significantly improved the outcome of cancer patients since its discovery. However, its clinical success remains limited due to the dose-dependent ... -
Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity : An evaluation of the protective role of melatonin.
(Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Introduction: Anthracyclines, such as doxorubicin (DXR), are among the most valuable treatments for various cancers, but their clinical use is limited due to detrimental side-effects such as cardiotoxicity. ... -
An evaluation of the hepatic proteomic signature in identifying cancer tolerance and resistance mechanisms in a mouse allograft system
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Background The unfavourable therapeutic index of most treatment modalities has greatly impeded progress in the development of effective cancer therapy. Therefore a need exists for treatment modalities ... -
Assessment of Metabolic Therapy for Acute Heart Failure
(Stellenbosch : Stellenbosch University, 2017-03)ENGLISH ABSTRACT: Introduction Acute heart failure (AHF) is the most common primary diagnosis for hospitalized heart disease cases in Africa. Increased fatty acid oxidation (FAO) with heart failure (HF) triggers detrimental ... -
The role of the AHNAK protein in breast cancer : implications for tumour metastasis and chemoresistance
(Stellenbosch : Stellenbosch University, 2016-12)ENGLISH ABSTRACT: Introduction – Cancer continues to have a significant impact on society. While there has been much success in characterising tumours and identifying targetable markers, two major problems are still faced ... -
Correlations between stress-associated anxiety and physiological determinants of health in adolescents
(Stellenbosch : Stellenbosch University, 2016-03)ENGLISH ABSTRACT: Anxiety disorders are among the most prevalent of psychiatric disorders across age groups, with onset typically in childhood or early adolescence, and risk for developing an anxiety disorder increasing ... -
Hyperglycemia-mediated onset of myocardial insulin resistance – unraveling molecular mechanisms and identifying therapeutic targets
(Stellenbosch : Stellenbosch University, 2014-04)ENGLISH ABSTRACT: Background - Although acute hyperglycemic episodes are linked to lower glucose uptake, underlying mechanisms driving this process remain unclear. We hypothesized that acute hyperglycemia triggers reactive ... -
The maladaptive effects of HIV protease inhibitors (Lopinavir/Ritonavir) on the rat heart.
(Stellenbosch : Stellenbosch University, 2013-12)ENGLISH ABSTRACT: Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term effects include onset of insulin resistance and cardiovascular diseases. Increased oxidative stress and dysregulation ... -
Manipulation of the autophagic pathway sensitises cervical cancer cells to cisplatin treatment
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Introduction Cisplatin has been widely used to treat solid tumours and much success has come from the use of this drug in the treatment of head and neck, ovarian, testicular, cervical and small-cell lung ... -
The hexosamine biosynthetic pathway induces gene promoter activity of the cardiac-enriched isoform of acetyl-CoA carboxylase
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: The cardiac isoform of acetyl-CoA carboxylase (ACCβ) produces malonyl-CoA, a potent inhibitor of mitochondrial fatty acid (FA) uptake; thus increased ACCβ activity decreases fatty acid utilization thereby ... -
Novel therapeutic agents that blunt hyperglycemia-induced cardiac contractile dysfunction
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Introduction Diabetes constitutes a major health challenge. Since cardiovascular complications are common in diabetic patients this will further increase the overall burden of disease. Furthermore, ... -
The contribution of inflammatory mediators to delayed secondary muscle damage
(Stellenbosch : Stellenbosch University, 2013-03)ENGLISH ABSTRACT: Background: Understanding the contribution of divergent individual response patterns remains a key objective in identifying mechanisms of inflammation and potential factors limiting the resolution of ... -
Faktore wat die prestasie en gesondheid van vroue-atlete kan beinvloed
(Stellenbosch : Stellenbosch University, 2003-12)ENGLISH ABSTRACT: Although it is common knowledge that regular exercise has many beneficial effects on the human body, it is also true that many highly competitive athletes neglect their health for the sake of performance. ... -
Differential effects of TNfα on satellite cell differentiation
(Stellenbosch : Stellenbosch University, 2007-03)ENGLISH ABSTRACT: Tumour necrosis factor alpha (TNFα) is a pleiotropic cytokine and has a wide variety of dose dependent cellular effects ranging from cell growth and differentiation, to inducing apoptosis. It has long ... -
Anthracycline-induced cardiotoxicity : the role of proteolytic pathways
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Introduction: The anthracyclines (ACs), daunorubicin (DNR) and doxorubicin (DXR) are two of the most effective drugs known for the treatment of systemic neoplasms and solid tumours. However, their ... -
Differential tolerance of a cancer and a non-cancer cell line to amino acid deprivation : mechanistic insight and clinical potential
(Stellenbosch : Stellenbosch University, 2012-03)ENGLISH ABSTRACT: Introduction – Due to spatial separation from the native vascular bed, solid tumours develop regions with limited access to nutrients essential for growth and survival. The promotion of a process known ... -
Dietary red palm oil-supplementation offers cardioprotection against Ischaemia/Reperfusion injury : possible cellular mechanisms involved
(Stellenbosch : University of Stellenbosch, 2005-12)ENGLISH ABSTRACT: Activation of the NO-cGMP pathway is associated with myocardial protection against ischaemia/reperfusion injury. However, high-cholesterol diets alter function of this pathway and these alterations have ... -
Exercise, stress and immune system functional responses
(Stellenbosch : University of Stellenbosch, 2004-12)ENGLISH ABSTRACT: Stress related to chronic exercise affects both the immune and endocrine systems, but there are still many issues that are poorly understood, particularly effects of stress on the functional capacity ... -
The association between genotype and BMI, health and lifestyle indicators as well as weight loss outcomes in overweight/obese Caucasian adults
(Stellenbosch : University of Stellenbosch, 2011-03)ENGLISH ABSTRACT: Genetic screening to improve obesity treatment outcomes is available despite the lack of conclusive evidence, specifically for Caucasian South Africans, in this regard. The aim of this study was to ...
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