Department of Biochemistry
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Disease- and treatment-associated acquired glucocorticoid resistance
(BioScientifica, 2018-10-11)ENGLISH ABSTRACT: The development of resistance to glucocorticoids (GCs) in therapeutic regimens poses a major threat. Generally, GC resistance is congenital or acquired over time as a result of disease progression, prolonged ... -
Data comparing the separation and elution of vitamin D metabolites on an ultra performance supercritical fluid chromatography tandem-mass spectrometer (UPSFC-MS/MS) compared to liquid chromatography (LC) and data presenting approaches to UPSFC method optimization
(Elsevier, 2018)The data presented is related to the research article "Analysis of multiple vitamin D metabolites by ultra performance supercritical fluid chromatography-tandem mass spectrometry (UPSFC-MS/MS)" (Jenkinson et al., 2018) ... -
Workflow for data analysis in experimental and computational systems biology : using Python as glue
(MDPI, 2019-07-18)ENGLISH ABSTRACT: Bottom-up systems biology entails the construction of kinetic models of cellular pathways by collecting kinetic information on the pathway components (e.g., enzymes) and collating this into a kinetic ... -
GR dimerization and the impact of GR dimerization on GR protein stability and half-life
(Frontiers Media, 2019-07-17)Pharmacologically, glucocorticoids, which mediate their effects via the glucocorticoid receptor (GR), are a most effective therapy for inflammatory diseases despite the fact that chronic use causes side-effects and ... -
Patterns of variation and chemosystematic significance of phenolic compounds in the genus cyclopia (fabaceae, podalyrieae)
(MDPI, 2019)ENGLISH ABSTRACT: As a contribution towards a better understanding of phenolic variation in the genus Cyclopia (honeybush tea), a collection of 82 samples from 15 of the 23 known species was analysed using liquid-chromat ... -
DNA vaccines against mycoplasma elicit humoral immune responses in ostriches
(Frontiers Media, 2019-05-14)In ostriches, the population densities resulting from intensive rearing increases susceptibility to pathogens such as mycoplasmas. In addition to good management practices, vaccination offers an attractive alternative ... -
A comparative analysis of within-host models of malaria infection with immune response
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: With growing resistance of malaria parasites to different antimalarial treatments, there is an ever present need for new investigative approaches into disease eradication. The symptoms of the disease ... -
The role of PFK in the oscillatory yeast strain X2180
(Stellenbosch : Stellenbosch University, 2019-04)ENGLISH ABSTRACT: The elucidation of mechanisms involved in glycolytic oscillations in yeast can lead to a deeper understanding of the metabolic organisation in living systems. These oscillations, detected in the ... -
Conservation implications of avian malaria exposure for African penguins during rehabilitation
(Academy of Science of South Africa, 2017-02-15)ENGLISH ABSTRACT: The African penguin (Spheniscus demersus) is the only penguin species that breeds on the African continent and it is currently classified as endangered. Its conservation is assisted by the Southern ... -
Delving deeper : relating the behaviour of a metabolic system to the properties of its components using symbolic metabolic control analysis
(Public Library of Science, 2018-11-28)High-level behaviour of metabolic systems results from the properties of, and interactions between, numerous molecular components. Reaching a complete understanding of metabolic behaviour based on the system’s components ... -
Evaluation of production and reproduction of three South African Angora goat CYP17 genotypes
(South African Society for Animal Science, 2017-06-05)Two CYP17 genes, located on different loci and expressing enzymes with significantly different activities, have been identified in the South African Angora goat population. Three unique genotypes (named He, Hu, and Ho), ... -
Targeting pathogen metabolism without collateral damage to the host
(Nature Research, 2017-01-13)The development of drugs that can inactivate disease-causing cells (e.g. cancer cells or parasites) without causing collateral damage to healthy or to host cells is complicated by the fact that many proteins are very similar ... -
Acetyl-4′-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency
(Nature Research, 2017-09-12)Coenzyme A is an essential metabolite known for its central role in over one hundred cellular metabolic reactions. In cells, Coenzyme A is synthesized de novo in five enzymatic steps with vitamin B5 as the starting metabolite, ... -
Simultaneous quantification of coenzyme A and its salvage pathway intermediates in in vitro and whole cell-sourced samples
(Royal Society of Chemistry, 2018-11-23)We report a method for the simultaneous quantification of the essential metabolic cofactor coenzyme A (CoA) and its thiol-bearing precursors—including 4′-phosphopantetheine, which was recently shown to play a potentially ... -
Systems biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus
(Public Library of Science, 2017-07-10)Sulfolobus solfataricus is a thermoacidophilic Archaeon that thrives in terrestrial hot springs (solfatares) with optimal growth at 80°C and pH 2–4. It catabolizes specific carbon sources, such as D-glucose, to pyruvate ... -
Identifiers for the 21st century : how to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data
(Public Library of Science, 2017-06-29)In many disciplines, data are highly decentralized across thousands of online databases (repositories, registries, and knowledgebases). Wringing value from such databases depends on the discipline of data science and on ... -
Targeted NGS for species level phylogenomics : "made to measure'' or "one size fits all''?
(PeerJ, 2017)Targeted high-throughput sequencing using hybrid-enrichment offers a promising source of data for inferring multiple, meaningfully resolved, independent gene trees suitable to address challenging phylogenetic problems ... -
FAIRDOMHub : a repository and collaboration environment for sharing systems biology research
(Oxford University Press on behalf of Nucleic Acids Research, 2017)The FAIRDOMHub is a repository for publishing FAIR (Findable, Accessible, Interoperable and Reusable) Data, Operating procedures and Models (https://fairdomhub.org/) for the Systems Biology community. It is a web-accessible ... -
Chemoprevention of LA7-induced mammary tumor growth by SM6Met, a well-characterized cyclopia extract
(Frontiers, 2018)Breast cancer (BC) is the leading cause of cancer-related deaths in women. Chemoprevention of BC by using plant extracts is gaining attention. SM6Met, a wellcharacterized extract of Cyclopia subternata with reported ... -
Novel role for receptor dimerization in post-translational processing and turnover of the GRα
(Nature, 2018)Glucocorticoids (GCs), acting via the glucocorticoid receptor (GRα), remain the mainstay therapeutic choice for the treatment of inflammation. However, chronic GC use, aside from generating undesirable side-effects, ...
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