Increased intracellular Ca2+ is necessary for maximal expression of the proto-oncogene c-jun in the Jurkat T-cell line
Date
1990
Authors
Vandenplas M.L.
Mouton W.L.
Vandenplas S.
Bester A.J.
Ricketts M.H.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The time course and signal-transduction requirements for proto-oncogene c-jun expression in T-cells were investigated. Expression of c-jun mRNA was evident at 30 min after stimulation. Both the activation of Ca2+/phospholipid-dependent kinase as well as an increased intracellular free Ca2+ concentration were necessary for the maximal induction of c-jun mRNA and synthesis of Jun protein 1 h after stimulation.
Description
Keywords
article, calcium cell level, cell culture, gene expression, human, human cell, leukemia cell line, oncogene, oncogene c jun, priority journal, signal transduction, t lymphocyte, cell line, drug effect, genetics, kinetics, metabolism, Northern blotting, physiology, proto oncogene, calcium, cycloheximide, DNA binding protein, DNA Binding Proteins, oncoprotein, phorbol 13 acetate 12 myristate, phytohemagglutinin, protein c jun, Proto Oncogene Proteins, Proto Oncogene Proteins c jun, transcription factor, Blotting, Northern, Calcium, Cell Line, Cycloheximide, DNA-Binding Proteins, Human, Kinetics, Phytohemagglutinins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-jun, Proto-Oncogenes, Signal Transduction, Support, Non-U.S. Gov't, Tetradecanoylphorbol Acetate, Transcription Factors, Tumor Cells, Cultured
Citation
Biochemical Journal
267
2
267
2