Increased intracellular Ca2+ is necessary for maximal expression of the proto-oncogene c-jun in the Jurkat T-cell line

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dc.contributor.authorVandenplas M.L.
dc.contributor.authorMouton W.L.
dc.contributor.authorVandenplas S.
dc.contributor.authorBester A.J.
dc.contributor.authorRicketts M.H.
dc.date.accessioned2011-05-15T16:03:24Z
dc.date.available2011-05-15T16:03:24Z
dc.date.issued1990
dc.description.abstractThe time course and signal-transduction requirements for proto-oncogene c-jun expression in T-cells were investigated. Expression of c-jun mRNA was evident at 30 min after stimulation. Both the activation of Ca2+/phospholipid-dependent kinase as well as an increased intracellular free Ca2+ concentration were necessary for the maximal induction of c-jun mRNA and synthesis of Jun protein 1 h after stimulation.
dc.description.versionArticle
dc.identifier.citationBiochemical Journal
dc.identifier.citation267
dc.identifier.citation2
dc.identifier.issn2646021
dc.identifier.urihttp://hdl.handle.net/10019.1/12604
dc.subjectarticle
dc.subjectcalcium cell level
dc.subjectcell culture
dc.subjectgene expression
dc.subjecthuman
dc.subjecthuman cell
dc.subjectleukemia cell line
dc.subjectoncogene
dc.subjectoncogene c jun
dc.subjectpriority journal
dc.subjectsignal transduction
dc.subjectt lymphocyte
dc.subjectcell line
dc.subjectdrug effect
dc.subjectgenetics
dc.subjectkinetics
dc.subjectmetabolism
dc.subjectNorthern blotting
dc.subjectphysiology
dc.subjectproto oncogene
dc.subjectcalcium
dc.subjectcycloheximide
dc.subjectDNA binding protein
dc.subjectDNA Binding Proteins
dc.subjectoncoprotein
dc.subjectphorbol 13 acetate 12 myristate
dc.subjectphytohemagglutinin
dc.subjectprotein c jun
dc.subjectProto Oncogene Proteins
dc.subjectProto Oncogene Proteins c jun
dc.subjecttranscription factor
dc.subjectBlotting, Northern
dc.subjectCalcium
dc.subjectCell Line
dc.subjectCycloheximide
dc.subjectDNA-Binding Proteins
dc.subjectHuman
dc.subjectKinetics
dc.subjectPhytohemagglutinins
dc.subjectProto-Oncogene Proteins
dc.subjectProto-Oncogene Proteins c-jun
dc.subjectProto-Oncogenes
dc.subjectSignal Transduction
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTetradecanoylphorbol Acetate
dc.subjectTranscription Factors
dc.subjectTumor Cells, Cultured
dc.titleIncreased intracellular Ca2+ is necessary for maximal expression of the proto-oncogene c-jun in the Jurkat T-cell line
dc.typeArticle
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