Surveillance of transmitted resistance to antiretroviral drug classes among young children in the western cape province of SOUTH AFRICA

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There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants. Copyright © 2010 by Lippincott Williams & Wilkins.
nevirapine, proteinase inhibitor, RNA directed DNA polymerase inhibitor, zidovudine, adolescent, analytic method, antiviral resistance, article, child, clinical article, drug surveillance program, genotype, highly active antiretroviral therapy, human, infant, mutation, preschool child, prevalence, priority journal, reverse transcription, school child, South Africa, treatment response, world health organization, Anti-HIV Agents, Drug Resistance, Viral, HIV Infections, HIV-1, Humans, Infant, Mutation, Population Surveillance, Prevalence, Reverse Transcriptase Inhibitors, South Africa, World Health Organization
Pediatric Infectious Disease Journal