Surveillance of transmitted resistance to antiretroviral drug classes among young children in the western cape province of SOUTH AFRICA

Van Zyl, G. U. ; Cotton, M. F. ; Claassen, M. ; Abrahams, C. ; Preiser, Wolfgang (2010)


There are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants. Copyright © 2010 by Lippincott Williams & Wilkins.

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