Surveillance of transmitted resistance to antiretroviral drug classes among young children in the western cape province of SOUTH AFRICA

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dc.contributor.authorVan Zyl, G. U.
dc.contributor.authorCotton, M. F.
dc.contributor.authorClaassen, M.
dc.contributor.authorAbrahams, C.
dc.contributor.authorPreiser, Wolfgangen_ZA
dc.date.accessioned2011-05-15T16:00:06Z
dc.date.available2011-05-15T16:00:06Z
dc.date.issued2010
dc.description.abstractThere are limited data on transmitted antiretroviral resistance in young children who require antiretroviral therapy. We adapted the World Health Organization surveillance strategy, testing antiretroviral naive infants (<18 months) in the Western Cape Province of South Africa, and detecting only 3 non-nucleoside reverse transcriptase inhibitors (NNRTI) and no NRTI or protease inhibitor surveillance mutations in 49 patients. The estimated NRTI and protease inhibitor transmitted antiretroviral resistance prevalence is low (<5%), predicting good therapeutic response in Western Cape infants. Copyright © 2010 by Lippincott Williams & Wilkins.
dc.description.versionArticle
dc.identifier.citationPediatric Infectious Disease Journal
dc.identifier.citation29
dc.identifier.citation4
dc.identifier.issn8913668
dc.identifier.other10.1097/INF.0b013e3181c4dada
dc.identifier.urihttp://hdl.handle.net/10019.1/11524
dc.subjectnevirapine
dc.subjectproteinase inhibitor
dc.subjectRNA directed DNA polymerase inhibitor
dc.subjectzidovudine
dc.subjectadolescent
dc.subjectanalytic method
dc.subjectantiviral resistance
dc.subjectarticle
dc.subjectchild
dc.subjectclinical article
dc.subjectdrug surveillance program
dc.subjectgenotype
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman
dc.subjectinfant
dc.subjectmutation
dc.subjectpreschool child
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectreverse transcription
dc.subjectschool child
dc.subjectSouth Africa
dc.subjecttreatment response
dc.subjectworld health organization
dc.subjectAnti-HIV Agents
dc.subjectDrug Resistance, Viral
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectInfant
dc.subjectMutation
dc.subjectPopulation Surveillance
dc.subjectPrevalence
dc.subjectReverse Transcriptase Inhibitors
dc.subjectSouth Africa
dc.subjectWorld Health Organization
dc.titleSurveillance of transmitted resistance to antiretroviral drug classes among young children in the western cape province of SOUTH AFRICA
dc.typeArticle
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