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Prevalence of amyloid blood clots in COVID-19 plasma

dc.contributor.authorPretorius, Etheresiaen_ZA
dc.contributor.authorVenter, Chantelleen_ZA
dc.contributor.authorLaubscher, Gert J.en_ZA
dc.contributor.authorLourens, Petrus J.en_ZA
dc.contributor.authorSteenkamp, Janamien_ZA
dc.contributor.authorKell, Douglas B.en_ZA
dc.date.accessioned2020-08-31T13:11:47Z
dc.date.available2020-08-31T13:11:47Z
dc.date.issued2020
dc.identifier.citationPretorius, E. et al. 2020. Prevalence of amyloid blood clots in COVID-19 plasma. medRxiv, doi:10.1101/2020.07.28.20163543.
dc.identifier.otherdoi:10.1101/2020.07.28.20163543
dc.identifier.urihttp://hdl.handle.net/10019.1/108769
dc.descriptionCITATION: Pretorius, E. et al. 2020. Prevalence of amyloid blood clots in COVID-19 plasma. medRxiv, doi:10.1101/2020.07.28.20163543.
dc.descriptionThe original publication is available at https://www.medrxiv.org
dc.description.abstractThe rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P<0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy.en_ZA
dc.description.urihttps://www.medrxiv.org/content/10.1101/2020.07.28.20163543v1
dc.format.extent14 pages
dc.language.isoen_ZAen_ZA
dc.publishermedRxiv
dc.subjectCOVID-19 (Disease)en_ZA
dc.subjectBlood -- Coagulationen_ZA
dc.subjectBlood plasmaen_ZA
dc.titlePrevalence of amyloid blood clots in COVID-19 plasmaen_ZA
dc.typeArticleen_ZA
dc.description.versionPre-print
dc.rights.holderAuthors retain copyright


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