Prevalence of amyloid blood clots in COVID-19 plasma
dc.contributor.author | Pretorius, Etheresia | en_ZA |
dc.contributor.author | Venter, Chantelle | en_ZA |
dc.contributor.author | Laubscher, Gert J. | en_ZA |
dc.contributor.author | Lourens, Petrus J. | en_ZA |
dc.contributor.author | Steenkamp, Janami | en_ZA |
dc.contributor.author | Kell, Douglas B. | en_ZA |
dc.date.accessioned | 2020-08-31T13:11:47Z | |
dc.date.available | 2020-08-31T13:11:47Z | |
dc.date.issued | 2020 | |
dc.description | CITATION: Pretorius, E. et al. 2020. Prevalence of amyloid blood clots in COVID-19 plasma. medRxiv, doi:10.1101/2020.07.28.20163543. | |
dc.description | The original publication is available at https://www.medrxiv.org | |
dc.description.abstract | The rapid detection of COVID-19 uses genotypic testing for the presence of SARS-Cov-2 virus in nasopharyngeal swabs, but it can have a poor sensitivity. A rapid, host-based physiological test that indicated whether the individual was infected or not would be highly desirable. Coagulaopathies are a common accompaniment to COVID-19, especially micro-clots within the lungs. We show here that microclots can be detected in the native plasma of COVID-19 patient, and in particular that such clots are amyloid in nature as judged by a standard fluorogenic stain. This provides a rapid and convenient test (P<0.0001), and suggests that the early detection and prevention of such clotting could have an important role in therapy. | en_ZA |
dc.description.uri | https://www.medrxiv.org/content/10.1101/2020.07.28.20163543v1 | |
dc.description.version | Pre-print | |
dc.format.extent | 14 pages | |
dc.identifier.citation | Pretorius, E. et al. 2020. Prevalence of amyloid blood clots in COVID-19 plasma. medRxiv, doi:10.1101/2020.07.28.20163543. | |
dc.identifier.other | doi:10.1101/2020.07.28.20163543 | |
dc.identifier.uri | http://hdl.handle.net/10019.1/108769 | |
dc.language.iso | en_ZA | en_ZA |
dc.publisher | medRxiv | |
dc.rights.holder | Authors retain copyright | |
dc.subject | COVID-19 (Disease) | en_ZA |
dc.subject | Blood -- Coagulation | en_ZA |
dc.subject | Blood plasma | en_ZA |
dc.title | Prevalence of amyloid blood clots in COVID-19 plasma | en_ZA |
dc.type | Article | en_ZA |