Sexual risk factors associated with volunteering for HIV vaccine research in South Africa
Date
2006
Authors
Smit J.
Middelkoop K.
Myer L.
Seedat S.
Wood R.
Stein D.J.
Bekker L.-G.
Journal Title
Journal ISSN
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Abstract
There are few data on how the risk profiles of individuals who volunteer for HIV vaccine research compare to the general population from which participants are recruited. This study contrasts demographic and sexual risk behaviours among volunteers in an HIV vaccine preparedness cohort with data from a cross-sectional community survey conducted in the same peri-urban community during the same time period. For the HIV vaccine preparedness cohort, structured questionnaires were administered to 140 HIV-negative individuals aged between 16 and 40 years. A questionnaire with identical measures was self-administered in a cross-sectional community survey of 583 randomly selected individuals within the same age range. Compared to the local community sample, individuals who volunteered for the HIV vaccine preparedness cohort were younger (adjusted odds ratio = 0.48; 95% CI = 0.28-0.82), more likely to have had a sexually transmitted disease (adjusted odds ratio = 1.75; 95% CI = 1.03-2.99) and less likely to use condoms (adjusted odds ratio = 0.51; 95% CI = 0.3-0.86). Cohort participants were also more likely to perceive themselves and their partners to be at risk of HIV infection, though these associations did not persist in multivariate analysis. These findings suggest that volunteers for vaccine-related research may be at greater risk of HIV infection than the general population from which they are recruited. © 2006 Taylor & Francis.
Description
Keywords
Human immunodeficiency virus vaccine, adolescent, adult, article, cohort analysis, community, comparative study, condom, confidence interval, controlled study, data analysis, demography, drug research, female, groups by age, high risk behavior, human, Human immunodeficiency virus infection, infection risk, major clinical study, male, multivariate analysis, prevalence, priority journal, questionnaire, risk assessment, risk factor, sexual behavior, sexuality, South Africa, urban population, volunteer, Adolescent, Adult, AIDS Vaccines, Biomedical Research, Cross-Sectional Studies, Female, HIV Infections, Human Experimentation, Humans, Male, Patient Acceptance of Health Care, Risk Factors, Risk-Taking, South Africa, Unsafe Sex
Citation
AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
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