Sexual risk factors associated with volunteering for HIV vaccine research in South Africa

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dc.contributor.authorSmit J.
dc.contributor.authorMiddelkoop K.
dc.contributor.authorMyer L.
dc.contributor.authorSeedat S.
dc.contributor.authorWood R.
dc.contributor.authorStein D.J.
dc.contributor.authorBekker L.-G.
dc.date.accessioned2011-05-15T15:58:50Z
dc.date.available2011-05-15T15:58:50Z
dc.date.issued2006
dc.description.abstractThere are few data on how the risk profiles of individuals who volunteer for HIV vaccine research compare to the general population from which participants are recruited. This study contrasts demographic and sexual risk behaviours among volunteers in an HIV vaccine preparedness cohort with data from a cross-sectional community survey conducted in the same peri-urban community during the same time period. For the HIV vaccine preparedness cohort, structured questionnaires were administered to 140 HIV-negative individuals aged between 16 and 40 years. A questionnaire with identical measures was self-administered in a cross-sectional community survey of 583 randomly selected individuals within the same age range. Compared to the local community sample, individuals who volunteered for the HIV vaccine preparedness cohort were younger (adjusted odds ratio = 0.48; 95% CI = 0.28-0.82), more likely to have had a sexually transmitted disease (adjusted odds ratio = 1.75; 95% CI = 1.03-2.99) and less likely to use condoms (adjusted odds ratio = 0.51; 95% CI = 0.3-0.86). Cohort participants were also more likely to perceive themselves and their partners to be at risk of HIV infection, though these associations did not persist in multivariate analysis. These findings suggest that volunteers for vaccine-related research may be at greater risk of HIV infection than the general population from which they are recruited. © 2006 Taylor & Francis.
dc.description.versionArticle
dc.identifier.citationAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
dc.identifier.citation18
dc.identifier.citation6
dc.identifier.issn9540121
dc.identifier.other10.1080/09540120500274976
dc.identifier.urihttp://hdl.handle.net/10019.1/10866
dc.subjectHuman immunodeficiency virus vaccine
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectcohort analysis
dc.subjectcommunity
dc.subjectcomparative study
dc.subjectcondom
dc.subjectconfidence interval
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectdemography
dc.subjectdrug research
dc.subjectfemale
dc.subjectgroups by age
dc.subjecthigh risk behavior
dc.subjecthuman
dc.subjectHuman immunodeficiency virus infection
dc.subjectinfection risk
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmultivariate analysis
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectquestionnaire
dc.subjectrisk assessment
dc.subjectrisk factor
dc.subjectsexual behavior
dc.subjectsexuality
dc.subjectSouth Africa
dc.subjecturban population
dc.subjectvolunteer
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAIDS Vaccines
dc.subjectBiomedical Research
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHuman Experimentation
dc.subjectHumans
dc.subjectMale
dc.subjectPatient Acceptance of Health Care
dc.subjectRisk Factors
dc.subjectRisk-Taking
dc.subjectSouth Africa
dc.subjectUnsafe Sex
dc.titleSexual risk factors associated with volunteering for HIV vaccine research in South Africa
dc.typeArticle
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