High heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease

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dc.contributor.authorCobat, A.
dc.contributor.authorGallant, C. J.
dc.contributor.authorSimkin, L.
dc.contributor.authorBlack, G. F.
dc.contributor.authorStanley, K.
dc.contributor.authorHughes, J.
dc.contributor.authorMark, Doherty T.
dc.contributor.authorHanekom, W. A.
dc.contributor.authorEley, B.
dc.contributor.authorBeyers, Nuldaen_ZA
dc.contributor.authorJais, J.-P.
dc.contributor.authorVan Helden, Paul D.en_ZA
dc.contributor.authorAbel, L.
dc.contributor.authorHoal, E. G.
dc.contributor.authorAlcais, A.
dc.contributor.authorSchurr, E.
dc.date.accessioned2011-05-15T16:03:33Z
dc.date.available2011-05-15T16:03:33Z
dc.date.issued2010
dc.description.abstractHuman antimycobacterial immunity is a critical component of tuberculosis (TB) pathogenesis that is often used to infer the presence of TB infection. We report high heritability (>50%) for in vitro secretion of tumor necrosis factor α and interferon γ (IFN-γ), and the frequency of antigen-specific IFN-γ+CD4+ and IFN- γ+CD8+ cells in the response of whole blood to mycobacterial challenge. In principal component analysis, the first 3 components explain 78% of the overall variance consistent with the effect of pleiotropic regulatory genes of human antimycobacterial immunity. These results directly demonstrate the pivotal role played by host genetics in quantitative measures of antimycobacterial immunity underlying immune diagnosis of TB infection. © 2010 by the Infectious Diseases Society of America. All rights reserved.
dc.description.versionArticle
dc.identifier.citationJournal of Infectious Diseases
dc.identifier.citation201
dc.identifier.citation1
dc.identifier.issn221899
dc.identifier.other10.1086/648611
dc.identifier.urihttp://hdl.handle.net/10019.1/12670
dc.subjectantimycobacterial agent
dc.subjectgamma interferon
dc.subjecttumor necrosis factor alpha
dc.subjectarticle
dc.subjectbacterial immunity
dc.subjectendemic disease
dc.subjectheritability
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectMycobacterium
dc.subjectpriority journal
dc.subjectquantitative analysis
dc.subjectregulator gene
dc.subjecttuberculosis
dc.subjectAdolescent
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectCD8-Positive T-Lymphocytes
dc.subjectCells, Cultured
dc.subjectChild
dc.subjectEndemic Diseases
dc.subjectFemale
dc.subjectGenotype
dc.subjectHumans
dc.subjectImmunity, Innate
dc.subjectInterferon-gamma
dc.subjectMale
dc.subjectMycobacterium tuberculosis
dc.subjectPhenotype
dc.subjectPrincipal Component Analysis
dc.subjectSouth Africa
dc.subjectTuberculosis
dc.subjectTumor Necrosis Factor-alpha
dc.subjectYoung Adult
dc.titleHigh heritability of antimycobacterial immunity in an area of hyperendemicity for tuberculosis disease
dc.typeArticle
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