Mechanical debridement with antibiotics in the treatment of chronic periodontitis : effect on systemic biomarkers― a systematic review
Date
2020-08
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
In this systematic review, we assessed the effectiveness of systemic antibiotics as an adjunctive therapy to mechanical debridement in improving inflammatory systemic biomarkers, as compared to mechanical debridement alone, among adults with chronic periodontitis. We searched relevant electronic databases for eligible randomized controlled trials. Two review authors independently screened, extracted data, and assessed risk of bias. We conducted meta-analysis, assessed heterogeneity, and assessed certainty of evidence using GRADEPro software. We included 19 studies (n = 1350 participants), representing 18 randomized controlled trials and found very little or no impact of antibiotics on inflammatory biomarkers. A meta-analysis of eight studies demonstrated a mean reduction of 0.26 mm in the periodontal pockets at three months (mean difference [MD] −0.26, 95%CI: −0.36 to −0.17, n = 372 participants, moderate certainty of evidence) in favor of the antibiotics. However, results from five studies reporting clinical attachment level (mm) yielded little or no difference at three months (MD −0.16, 95% CI: −0.35 to 0.03, n = 217 participants) between antibiotic and placebo groups. There is little or no evidence that adjunctive systemic antibiotics therapy improves inflammatory systemic biomarkers, compared to mechanical debridement alone, among adults with chronic periodontitis.
Description
CITATION: Munasur, S. L. et al. 2020. Mechanical Debridement with Antibiotics in the Treatment of Chronic Periodontitis: Effect on Systemic Biomarkers―A Systematic Review. International Journal of Environmental Research and Public Health, 17(15). doi:10.3390/ijerph17155601
The original publication is available at https://www.mdpi.com/journal/ijerph
The original publication is available at https://www.mdpi.com/journal/ijerph
Keywords
Periodontitis -- Treatment, Periodontal disease, Periodontal therapy
Citation
Munasur, S. L. et al. 2020. Mechanical Debridement with Antibiotics in the Treatment of Chronic Periodontitis: Effect on Systemic Biomarkers―A Systematic Review. International Journal of Environmental Research and Public Health, 17(15). doi:10.3390/ijerph17155601