10Kin1day : a bottom-up neuroimaging initiative

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dc.contributor.authorVan den Heuvel, Martijn P.en_ZA
dc.contributor.authorScholtens, Lianne H.en_ZA
dc.contributor.authorVan der Burgh, Hannelore K.en_ZA
dc.contributor.authorAgosta, Federicaen_ZA
dc.contributor.authorAlloza, Claraen_ZA
dc.contributor.authorArango, Celsoen_ZA
dc.contributor.authorAuyeung, Bonnieen_ZA
dc.contributor.authorBaron-Cohen, Simonen_ZA
dc.contributor.authorBasaia, Silviaen_ZA
dc.contributor.authorBenders, Manon J. N. L.en_ZA
dc.contributor.authorBeyer, Fraukeen_ZA
dc.contributor.authorBooij, Lindaen_ZA
dc.contributor.authorBraun, Kees P. J.en_ZA
dc.contributor.authorFilho, Geraldo Busattoen_ZA
dc.contributor.authorCahn, Wiepkeen_ZA
dc.contributor.authorCannon, Dara M.en_ZA
dc.contributor.authorChaim-Avancini, Tiffany M.en_ZA
dc.contributor.authorChan, Sandra S. M.en_ZA
dc.contributor.authorChen, Eric Y. H.en_ZA
dc.contributor.authorCrespo-Facorro, Benedictoen_ZA
dc.contributor.authorCrone, Eveline A.en_ZA
dc.contributor.authorDannlowski, Udoen_ZA
dc.contributor.authorDe Zwarte, Sonja M. C.en_ZA
dc.contributor.authorDietsche, Brunoen_ZA
dc.contributor.authorDonohoe, Garyen_ZA
dc.contributor.authorDu Plessis, Stefanen_ZA
dc.contributor.authorDurston, Sarahen_ZA
dc.contributor.authorDiaz-Caneja, Covadonga M.en_ZA
dc.contributor.authorDíaz-Zuluaga, Ana M.en_ZA
dc.contributor.authorEmsley, Robinen_ZA
dc.contributor.authorFilippi, Massimoen_ZA
dc.contributor.authorFrodl, Thomasen_ZA
dc.contributor.authorGorges, Martinen_ZA
dc.contributor.authorGraff, Beataen_ZA
dc.contributor.authorGrotegerd, Dominiken_ZA
dc.contributor.authorGąsecki, Dariuszen_ZA
dc.contributor.authorHall, Julie M.en_ZA
dc.contributor.authorHolleran, Laurenaen_ZA
dc.contributor.authorHolt, Rosemaryen_ZA
dc.contributor.authorHopman, Helene J.en_ZA
dc.contributor.authorJansen, Andreasen_ZA
dc.contributor.authorJanssen, Joosten_ZA
dc.contributor.authorJodzio, Krzysztofen_ZA
dc.contributor.authorJancke, Lutzen_ZA
dc.contributor.authorKaleda, Vasiliy G.en_ZA
dc.contributor.authorKassubek, Janen_ZA
dc.contributor.authorMasouleh, Shahrzad Kharabianen_ZA
dc.contributor.authorKircher, Tiloen_ZA
dc.contributor.authorKoevoets, Martijn G. J. C.en_ZA
dc.contributor.authorKostic, Vladimir S.en_ZA
dc.contributor.authorKrug, Axelen_ZA
dc.contributor.authorLawrie, Stephen M.en_ZA
dc.contributor.authorLebedeva, Irina S.en_ZA
dc.contributor.authorLee, Edwin H. M.en_ZA
dc.contributor.authorLett, Tristram A.en_ZA
dc.contributor.authorLewis, Simon J. G.en_ZA
dc.contributor.authorLiem, Franziskusen_ZA
dc.contributor.authorLombardo, Michael V.en_ZA
dc.contributor.authorLopez-Jaramillo, Carlosen_ZA
dc.contributor.authorMargulies, Daniel S.en_ZA
dc.contributor.authorMarkett, Sebastianen_ZA
dc.contributor.authorMarques, Pauloen_ZA
dc.contributor.authorMartinez-Zalacaín, Ignacioen_ZA
dc.contributor.authorMcDonald, Colmen_ZA
dc.contributor.authorMcIntosh, Andrew M.en_ZA
dc.contributor.authorMcPhilemy, Genevieveen_ZA
dc.contributor.authorMeinert, Susanne L.en_ZA
dc.contributor.authorMenchon, Jose M.en_ZA
dc.contributor.authorMontag, Christianen_ZA
dc.contributor.authorMoreira, Pedro S.en_ZA
dc.contributor.authorMorgado, Pedroen_ZA
dc.contributor.authorMothersill, David O.en_ZA
dc.contributor.authorMerillat, Susanen_ZA
dc.contributor.authorMuller, Hans-Peteren_ZA
dc.contributor.authorNabulsi, Leilaen_ZA
dc.contributor.authorNajt, Pabloen_ZA
dc.contributor.authorNarkiewicz, Krzysztofen_ZA
dc.contributor.authorNaumczyk, Patrycjaen_ZA
dc.contributor.authorOranje, Boben_ZA
dc.contributor.authorDe la Foz, Victor Ortiz-Garciaen_ZA
dc.contributor.authorPeper, Jiska S.en_ZA
dc.contributor.authorPineda, Julian A.en_ZA
dc.contributor.authorRasser, Paul E.en_ZA
dc.contributor.authorRedlich, Ronnyen_ZA
dc.contributor.authorRepple, Jonathanen_ZA
dc.contributor.authorReuter, Martinen_ZA
dc.contributor.authorRosa, Pedro G. P.en_ZA
dc.contributor.authorRuigrok, Amber N. V.en_ZA
dc.contributor.authorSabisz, Agnieszkaen_ZA
dc.contributor.authorSchall, Ulrichen_ZA
dc.contributor.authorSeedat, Soraya, 1966-en_ZA
dc.contributor.authorSerpa, Mauricio H.en_ZA
dc.contributor.authorSkouras, Stavrosen_ZA
dc.contributor.authorSoriano-Mas, Carlesen_ZA
dc.contributor.authorSousa, Nunoen_ZA
dc.contributor.authorSzurowska, Edytaen_ZA
dc.contributor.authorTomyshev, Alexander S.en_ZA
dc.contributor.authorTordesillas-Gutierrez, Dianaen_ZA
dc.contributor.authorValk, Sofie L.en_ZA
dc.contributor.authorVan den Berg, Leonard H.en_ZA
dc.contributor.authorVan Erp, Theo G. M.en_ZA
dc.contributor.authorVan Haren, Neeltje E. M.en_ZA
dc.contributor.authorVan Leeuwen, Judith M. C.en_ZA
dc.contributor.authorVillringer, Arnoen_ZA
dc.contributor.authorVinkers, Christiaan H.en_ZA
dc.contributor.authorVollmar, Christianen_ZA
dc.contributor.authorWaller, Leaen_ZA
dc.contributor.authorWalter, Henriken_ZA
dc.contributor.authorVillringer, Arnoen_ZA
dc.contributor.authorVinkers, Christiaan H.en_ZA
dc.contributor.authorVollmar, Christianen_ZA
dc.contributor.authorWaller, Leaen_ZA
dc.contributor.authorWalter, Henriken_ZA
dc.contributor.authorWhalley, Heather C.en_ZA
dc.contributor.authorWitkowska, Martaen_ZA
dc.contributor.authorWitte, A. Veronicaen_ZA
dc.contributor.authorZanetti, Marcus V.en_ZA
dc.contributor.authorZhang, Ruien_ZA
dc.contributor.authorDe Lange, Siemon C.en_ZA
dc.date.accessioned2021-11-05T06:48:23Z
dc.date.available2021-11-05T06:48:23Z
dc.date.issued2019
dc.descriptionCITATION: Van Den Heuvel, M. P., et al. 2019. 10Kin1day : a bottom-up neuroimaging initiative. Frontiers in Neurology, 10:425, doi:10.3389/fneur.2019.00425.
dc.descriptionThe original publication is available at https://www.frontiersin.org
dc.description.abstractParkinson’s disease (PD) is a well-known neurodegenerative disease with a strong association established with systemic inflammation. Recently, the role of the gingipain protease group from Porphyromonas gingivalis was implicated in Alzheimer’s disease and here we present evidence, using a fluorescent antibody to detect gingipain R1 (RgpA), of its presence in a PD population. To further elucidate the action of this gingipain, as well as the action of the lipopolysaccharide (LPS) from P. gingivalis, low concentrations of recombinant RgpA and LPS were added to purified fluorescent fibrinogen. We also substantiate previous findings regarding PD by emphasizing the presence of systemic inflammation via multiplex cytokine analysis, and demonstrate hypercoagulation using thromboelastography (TEG), confocal and electron microscopy. Biomarker analysis confirmed significantly increased levels of circulating proinflammatory cytokines. In our PD and control blood analysis, our results show increased hypercoagulation, the presence of amyloid formation in plasma, and profound ultrastructural changes to platelets. Our laboratory analysis of purified fibrinogen with added RgpA, and/or LPS, showed preliminary data with regards to the actions of the protease and the bacterial membrane inflammagen on plasma proteins, to better understand the nature of established PD.en_ZA
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fneur.2019.00425/full
dc.description.versionFrontiers Media
dc.format.extent7 pages ; illustrations
dc.identifier.citationVan Den Heuvel, M. P., et al. 2019. 10Kin1day : a bottom-up neuroimaging initiative. Frontiers in Neurology, 10:425, doi:10.3389/fneur.2019.00425
dc.identifier.issn1664-2295 (online)
dc.identifier.otherdoi:10.3389/fneur.2019.00425
dc.identifier.urihttp://hdl.handle.net/10019.1/123366
dc.language.isoen_ZAen_ZA
dc.publisherFrontiers Media
dc.rights.holderAuthors retain copyright
dc.subjectBrain -- Imagingen_ZA
dc.subjectMagnetic resonance imagingen_ZA
dc.subjectDiffusion magnetic resonance imagingen_ZA
dc.subjectBrain mappingen_ZA
dc.subjectConnectome analysisen_ZA
dc.title10Kin1day : a bottom-up neuroimaging initiativeen_ZA
dc.typeArticleen_ZA
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