An outbreak of drug-resistant tuberculosis caused by a Beijing strain in the Western Cape, South Africa

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dc.contributor.authorJohnson R.
dc.contributor.authorWarren R.
dc.contributor.authorStrauss O.J.
dc.contributor.authorJordaan A.M.
dc.contributor.authorFalmer A.A.
dc.contributor.authorBeyers N.
dc.contributor.authorSchaaf H.S.
dc.contributor.authorMurray M.
dc.contributor.authorCloete K.
dc.contributor.authorVan Helden P.D.
dc.contributor.authorVictor T.C.
dc.date.accessioned2011-05-15T15:53:49Z
dc.date.available2011-05-15T15:53:49Z
dc.date.issued2006
dc.description.abstractDuring October 2005, four children in a school in Cape Town were identified with multidrug-resistant tuberculosis (MDR-TB). Genetic analysis confirmed that these isolates belonged to a single cluster (Beijing cluster 220) and that all harboured a -15 inhAC-T promoter mutation demonstrating transmission. Genetic analysis of isolates cultured from patients from the Boland-Overberg-South Cape-Karoo and Cape Town regions showed that 28% (58/209) of patients infected with a Beijing strain had the cluster 220 genotypes and that all harboured the same -15 inhAC-T promoter mutation. The presence of these transmissible MDR-TB strains may pose a threat to the community, and rigorous infection control measures are needed to ensure the safety of those exposed. © 2006 The Union.
dc.description.versionArticle
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease
dc.identifier.citation10
dc.identifier.citation12
dc.identifier.issn10273719
dc.identifier.urihttp://hdl.handle.net/10019.1/8834
dc.titleAn outbreak of drug-resistant tuberculosis caused by a Beijing strain in the Western Cape, South Africa
dc.typeArticle
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