Thrombocytopoenia as marker for HIV exposure in the neonate

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dc.contributor.authorRoux W.
dc.contributor.authorPieper C.
dc.contributor.authorCotton M.
dc.date.accessioned2011-05-15T16:02:04Z
dc.date.available2011-05-15T16:02:04Z
dc.date.issued2001
dc.description.abstractThrombocytopoenia is a well-described marker of human immunedeficiency virus type 1 (HIV) infection of children. After documenting thrombocytopoenia in a HIV-exposed neonate, who was subsequently shown not to be infected, we evaluated thrombocytopoenia (platelets < 150 × 109/I) as a marker for HIV exposure in newborns. This is, to our knowledge, the first study of thrombocytopoenia in HIV-exposed neonates. A retrospective hospital-based descriptive study was performed over an 18-month period (July 1997-December 1998). Patients were recruited either through identification of known HIV-positive mothers or neonates with thrombocytopoenia who were then screened for HIV exposure. For eligibility, neonates with either HIV antibodies or direct evidence of infection (p24 antigenaemia or HIV RNA detected by polymerase chain reaction after 1 month of age) were included. Thirty-four HIV-exposed (HIV-ELISA positive) neonates were identified, of whom 16 (47 per cent) had thrombocytopenia. In 12 (35 per cent), no underlying cause other than HIV was identified. Nine thrombocytopoenic babies were infected and seven uninfected. Unexplained thrombocytopoenia, while an imperfect marker, should alert the physician to the possibility of HIV exposure. It does not necessarily imply HIV infection. A prospective study is recommended to evaluate further the sensitivity and specificity of this marker.
dc.description.versionArticle
dc.identifier.citationJournal of Tropical Pediatrics
dc.identifier.citation47
dc.identifier.citation4
dc.identifier.issn1426338
dc.identifier.other10.1093/tropej/47.4.208
dc.identifier.urihttp://hdl.handle.net/10019.1/12290
dc.subjectGag protein
dc.subjectHuman immunodeficiency virus antibody
dc.subjectvirus RNA
dc.subjectage
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease marker
dc.subjectenzyme linked immunosorbent assay
dc.subjectexposure
dc.subjecthospital
dc.subjecthuman
dc.subjectHuman immunodeficiency virus 1
dc.subjectHuman immunodeficiency virus infection
dc.subjectmedical documentation
dc.subjectnewborn
dc.subjectnewborn screening
dc.subjectpolymerase chain reaction
dc.subjectprospective study
dc.subjectretrospective study
dc.subjectsensitivity and specificity
dc.subjectthrombocyte count
dc.subjectthrombocytopenia
dc.subjectBiological Markers
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectPolymerase Chain Reaction
dc.subjectPregnancy
dc.subjectPrenatal Exposure Delayed Effects
dc.subjectRetrospective Studies
dc.subjectSouth Africa
dc.subjectThrombocytopenia
dc.titleThrombocytopoenia as marker for HIV exposure in the neonate
dc.typeArticle
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