The effect of ionizing radiation on the primate pancreas: An endocrine and morphologic study

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dc.contributor.authorDu Toit D.F.
dc.contributor.authorHeydenrych J.J.
dc.contributor.authorSmith B.
dc.date.accessioned2011-05-15T16:05:06Z
dc.date.available2011-05-15T16:05:06Z
dc.date.issued1987
dc.description.abstractIn this study we evaluated the endocrine, biochemical, and haematological derangements as well as pancreatic and histological changes of the bone-marrow in the primate following external fractionated subtotal marrow irradiation without bonemarrow reconstitution. The irradiation was administered in preparation for pancreatic transplantation. Two groups of animals (ten in each group) received 800 rad (8 Gy) and 1,000 rad (10 Gy) respectively over 4 to 5 weeks. A maximum of 200 rads (2 Gy) were administered weekly as photons from a 6 MV linear accelerator. During irradiation the animals remained normoglycaemic in the presence of transiently elevated liver enzymes and serum amylase values, which returned to normal on completion of the irradiation. Insulin release was significantly reduced in both groups during irradiation and was associated with minimally decreased K-values in the presence of mild glucose intolerance. Pancreatic light morphologic changes included structural changes of both exocrine and endocrine elements and included necrosis of the islet cells and acinar tissue. Islet histology demonstrated striking cytocavitary network changes of alpha and beta cells, including degranulation, vacuolization, mitochondrial destruction, and an increase in lysosomes. A hypoplastic bonemarrow ranging from moderate to severe was observed in all irradiated recipients. Near total fractionated body irradiation in the primate is therefore associated with elevated liver enzymes, pancytopenia, transient hyperamylasaemia, hypoinsulinaemia, a varying degree of pancreatitis, and bonemarrow hypoplasia.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation34
dc.identifier.citation1
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12969
dc.subjectelectron microscopy
dc.subjectendocrine function
dc.subjecthistology
dc.subjecthistopathology
dc.subjectinjury
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectpancreas
dc.subjectpriority journal
dc.subjectradiation injury
dc.subjecttherapy
dc.subjectultrastructure
dc.subjectAnimal
dc.subjectBone Marrow
dc.subjectFemale
dc.subjectGlucose Tolerance Test
dc.subjectImmunoenzyme Techniques
dc.subjectInsulin
dc.subjectMale
dc.subjectNecrosis
dc.subjectPancreas
dc.subjectPancreatectomy
dc.subjectPapio
dc.subjectRadiation Dosage
dc.subjectRadiation Injuries, Experimental
dc.subjectSupport, Non-U.S. Gov't
dc.subjectWhole-Body Irradiation
dc.titleThe effect of ionizing radiation on the primate pancreas: An endocrine and morphologic study
dc.typeArticle
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