Inferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization

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dc.contributor.authorMadhi S.A.
dc.contributor.authorViolari A.
dc.contributor.authorKlugman K.P.
dc.contributor.authorLin G.
dc.contributor.authorMcIntyre J.A.
dc.contributor.authorvon Gottberg A.
dc.contributor.authorJean-Philippe P.
dc.contributor.authorCotton M.F.
dc.contributor.authorAdrian P.
dc.date.accessioned2011-10-13T16:58:55Z
dc.date.available2011-10-13T16:58:55Z
dc.date.issued2011
dc.description.abstractBackground: Heightened immunogenicity, measured one month after the primary series of pneumococcal conjugate vaccine (PCV), in African children was previously hypothesized to be due to increased rates of nasopharyngeal pneumococcal colonization during early infancy. Methods: We analyzed the effect of selected vaccine-serotype (6B, 19F and 23F) nasopharyngeal colonization prior to the first PCV dose or when colonized for the first time prior to the second or third (2nd/3rd) PCV dose on serotype quantitative and qualitative antibody responses. Results: Colonization prior to receiving the first PCV was associated with lower geometric mean antibody concentrations (GMCs) one month after the third dose of PCV and six months later to the colonizing-serotype. Colonized infants also had lower geometric mean titers (GMTs) on opsonophagocytosis activity assay (OPA) and a lower proportion had titers ≥8 against the colonizing serotypes (19F and 23F) post vaccination. Colonization occurring only prior to the 2nd/3rdPCV dose was also associated with lower GMCs and OPA GMTs to the colonizing-serotype. The effect of colonization with serotypes 19F and 23F prior to PCV vaccination had a greater effect on a lower proportion of colonized infants having OPA titers ≥8 than the effect of colonization on the lower proportion with antibody ≥0.35 μg/ml. Conclusion: Infant nasopharyngeal colonization at any stage before completing the primary series of PCV vaccination was associated with inferior quantitative and qualitative antibody responses to the colonizing-serotype. © 2011 Elsevier Ltd.
dc.description.versionArticle
dc.identifier.citationVaccine
dc.identifier.citation29
dc.identifier.citation40
dc.identifier.citationhttp://www.scopus.com/inward/record.url?eid=2-s2.0-80052340389&partnerID=40&md5=1486c5c547f568a49c8e295a99131b70
dc.identifier.issn0264410X
dc.identifier.other10.1016/j.vaccine.2011.07.035
dc.identifier.urihttp://hdl.handle.net/10019.1/16911
dc.subjectColonization
dc.subjectHIV
dc.subjectHypo-responsiveness
dc.subjectImmunogenicity
dc.subjectPneumococcal conjugate vaccine
dc.subjectStreptococcus pneumoniae
dc.subjectpneumococcal conjugate vaccine
dc.subjectPneumococcus vaccine
dc.subjectunclassified drug
dc.subjectantibody blood level
dc.subjectantibody response
dc.subjectantibody titer
dc.subjectarticle
dc.subjectbacterial colonization
dc.subjectchild
dc.subjectcomparative study
dc.subjectfemale
dc.subjectgeometric mean antibody concentration
dc.subjectgeometric mean titer
dc.subjecthuman
dc.subjectimmune response
dc.subjectimmunization
dc.subjectinfant
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnasopharyngeal colonization
dc.subjectopsonophagocytosis activity assay
dc.subjectphagocytosis
dc.subjectpriority journal
dc.subjectqualitative antibody response
dc.subjectquantitative antibody response
dc.subjectserotype
dc.subjectStreptococcus pneumoniae
dc.titleInferior quantitative and qualitative immune responses to pneumococcal conjugate vaccine in infants with nasopharyngeal colonization by Streptococcus pneumoniae during the primary series of immunization
dc.typeArticle
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