Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration

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dc.contributor.authorMoller M.
dc.contributor.authorDu Preez J.L.
dc.contributor.authorEmsley R.
dc.contributor.authorHarvey B.H.
dc.date.accessioned2011-05-25T08:49:50Z
dc.date.available2011-05-25T08:49:50Z
dc.date.issued2011
dc.description.abstractSocial isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR increased superoxide dismutase activity, decreased oxidized:reduced glutathione ratio and increased lipid peroxidation in both brain regions, and induced deficits in prepulse inhibition and social and self-directed interactive behaviors. Both behavioral and cortico-striatal redox disturbances were corrected by clozapine (5 mg/kg/day. × 11 days). Behavioral changes evoked by SIR are associated with cortico-striatal oxidative stress that is reversed by clozapine treatment, providing novel insight into the neurobiology and treatment of schizophrenia. © 2010 Elsevier B.V.
dc.description.versionArticle
dc.identifier.citationEuropean Neuropsychopharmacology
dc.identifier.citation21
dc.identifier.citation6
dc.identifier.citation471
dc.identifier.citation483
dc.identifier.issn0924977X
dc.identifier.other10.1016/j.euroneuro.2010.09.006
dc.identifier.urihttp://hdl.handle.net/10019.1/14709
dc.titleIsolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration
dc.typeArticle
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