Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

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dc.contributor.authorScriba T.J.
dc.contributor.authorTreurnicht F.K.
dc.contributor.authorZeier M.
dc.contributor.authorEngelbrecht S.
dc.contributor.authorVan Rensburg E.J.
dc.date.accessioned2011-05-15T16:03:22Z
dc.date.available2011-05-15T16:03:22Z
dc.date.issued2001
dc.description.abstractTo acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.
dc.description.versionArticle
dc.identifier.citationAIDS Research and Human Retroviruses
dc.identifier.citation17
dc.identifier.citation8
dc.identifier.issn8892229
dc.identifier.other10.1089/088922201750237059
dc.identifier.urihttp://hdl.handle.net/10019.1/12591
dc.subjectHuman immunodeficiency virus vaccine
dc.subjectVif protein
dc.subjectVpr protein
dc.subjectVpu protein
dc.subjectamino acid sequence
dc.subjectarticle
dc.subjectcarboxy terminal sequence
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene isolation
dc.subjectgenetic analysis
dc.subjectgeographic distribution
dc.subjecthuman
dc.subjectHuman immunodeficiency virus 1
dc.subjectmale
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectpriority journal
dc.subjectprotein phosphorylation
dc.subjectSouth Africa
dc.subjectvirus characterization
dc.subjectvirus strain
dc.subjectAIDS Vaccines
dc.subjectAmino Acid Sequence
dc.subjectFemale
dc.subjectGenes, vif
dc.subjectGenes, Viral
dc.subjectGenes, vpr
dc.subjectGenes, vpu
dc.subjectHIV Infections
dc.subjectHIV-1
dc.subjectHumans
dc.subjectMale
dc.subjectMolecular Sequence Data
dc.subjectPhylogeny
dc.subjectSequence Alignment
dc.subjectSouth Africa
dc.subjectVariation (Genetics)
dc.titleCharacterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes
dc.typeArticle
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