Early postoperative pancreatic endocrine function after segmental and pancreaticoduodenal allotransplantation in nonimmunosuppressed primates

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dc.contributor.authorDu Toit, D. F.
dc.contributor.authorHeydenrych, J. J.
dc.contributor.authorSmit, B.
dc.date.accessioned2011-05-15T16:05:05Z
dc.date.available2011-05-15T16:05:05Z
dc.date.issued1987
dc.description.abstractIn this study we evaluated the short-term hormonal effects of segmental and whole pancreatic allotransplantation on the glucose intolerance produced by hemipancreatectomy in the primate. In hemipancreatectomized animals without grafts the K-values were reduced to 0.6 ± 0.05, plasma insulin increased from 27.5 ± 2.5 to 63.5 ± 6.3 μU/ml, and glucagon levels declined from 252 ± 29.9 to 216.5 ± 33.0 pg/ml. Hemipancreatectomized segmental allograft recipients rendered K-values of 0.79 ± 0.05, plasma insulin increased from 19.98 ± 3.43 to 66.0 ± 17.03 μU/ml, and glucagon release declined from 395.6 ± 63.0 to 226.2 ± 37.6 pg/ml during IVGTT postoperatively. Hemipancreatectomized, pancreaticoduodenal allograft recipients rendered K-values of 0.82 ± 0.1, results not significantly different from hemipancreatectomized or segmental allograft recipients. Plasma insulin increased from 29.5 ± 4.0 to 186.0 ± 25.0 μU/ml, and glucagon release declined from 1,087.0 ± 31.6 to 656.0 ± 12.7 pg/ml. In summary, segmental pancreatic allotransplantation could not, in the short-term, restore the reduced K-values and hypoinsulinaemia in hemipancreatectomized primates to that of normal, unstressed controls. Although K-values of hemipancreatectomized recipients were not significantly improved, whole pancreas transplantation resulted in improved insulin release and hyperglucagonaemia during IVGTT when compared to segmental allograft recipients. The unexpected findings of hypoinsulinaemia and hyperglucagonaemia in both transplant groups may only reflect a function of the stressed state of the animals in the immediate postoperative phase.
dc.description.versionArticle
dc.identifier.citationJournal of Surgical Oncology
dc.identifier.citation34
dc.identifier.citation4
dc.identifier.issn224790
dc.identifier.urihttp://hdl.handle.net/10019.1/12968
dc.subjectglucagon
dc.subjectinsulin
dc.subjectanimal experiment
dc.subjectendocrine system
dc.subjectglucose intolerance
dc.subjectmonkey
dc.subjectnonhuman
dc.subjectpancreas
dc.subjectpancreas resection
dc.subjectpancreas transplantation
dc.subjectpriority journal
dc.subjectAnimal
dc.subjectBlood Glucose
dc.subjectComparative Study
dc.subjectDuodenum
dc.subjectGlucagon
dc.subjectGlucose Tolerance Test
dc.subjectImmunosuppression
dc.subjectInsulin
dc.subjectIslets of Langerhans
dc.subjectMethods
dc.subjectPancreas Transplantation
dc.subjectPancreatectomy
dc.subjectPapio
dc.subjectPostoperative Period
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTransplantation, Homologous
dc.titleEarly postoperative pancreatic endocrine function after segmental and pancreaticoduodenal allotransplantation in nonimmunosuppressed primates
dc.typeArticle
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