Partial response to antipsychotic treatment: The patient with enduring symptoms

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dc.contributor.authorEmsley R.A.
dc.date.accessioned2011-05-15T16:01:57Z
dc.date.available2011-05-15T16:01:57Z
dc.date.issued1999
dc.description.abstractWhile approximately 70% of patients with schizophrenia and other psychotic disorders show a clear-cut reduction of symptoms in clinical trials, there is considerable variation in individual patient outcome, ranging from complete remission to absolute refractoriness. When additional indicators of treatment outcome are considered, such as cognitive and occupational and social functioning, it is clear that the overall outcome for schizophrenia is far from satisfactory. For many schizophrenic patients, treatment with conventional antipsychotic agents is not fully effective, and one approach has been to increase the administered dose. However, raising the dose increases the likelihood of side effects and may significantly compromise patient compliance. The availability of atypical antipsychotic agents represents a significant step forward for those patients who are nonresponsive to conventional antipsychotics, offering proven efficacy, a lower risk of extrapyramidal symptoms, and improved clinical outcomes.
dc.description.versionArticle
dc.identifier.citationJournal of Clinical Psychiatry
dc.identifier.citation60
dc.identifier.citationSUPPL. 23
dc.identifier.issn1606689
dc.identifier.urihttp://hdl.handle.net/10019.1/12237
dc.subjectfluphenazine
dc.subjecthaloperidol
dc.subjectquetiapine
dc.subjectarticle
dc.subjectcognition
dc.subjectdrug efficacy
dc.subjectextrapyramidal symptom
dc.subjecthuman
dc.subjectpriority journal
dc.subjectpsychosis
dc.subjectremission
dc.subjectschizophrenia
dc.subjectsocial status
dc.subjecttreatment outcome
dc.subjectAdult
dc.subjectAged
dc.subjectAntipsychotic Agents
dc.subjectBasal Ganglia Diseases
dc.subjectClinical Trials
dc.subjectDibenzothiazepines
dc.subjectDose-Response Relationship, Drug
dc.subjectDrug Administration Schedule
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectPatient Compliance
dc.subjectPsychiatric Status Rating Scales
dc.subjectPsychotic Disorders
dc.subjectSchizophrenia
dc.subjectSchizophrenic Psychology
dc.subjectTreatment Outcome
dc.titlePartial response to antipsychotic treatment: The patient with enduring symptoms
dc.typeArticle
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