Transmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling 'strain W' among noninstitutionalized, human immunodeficiency virus-seronegative patients

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dc.contributor.authorVan Annelies R.
dc.contributor.authorWarren R.M.
dc.contributor.authorBeyers N.
dc.contributor.authorGie R.P.
dc.contributor.authorClassen C.N.
dc.contributor.authorRichardson M.
dc.contributor.authorSampson S.L.
dc.contributor.authorVictor T.C.
dc.contributor.authorVan Helden P.D.
dc.date.accessioned2011-05-15T16:03:34Z
dc.date.available2011-05-15T16:03:34Z
dc.date.issued1999
dc.description.abstractSince 1990, several outbreaks of multidrug-resistant tuberculosis (MDR- TB) have been described among institutionalized patients infected with human immunodeficiency virus (HIV). We describe a community MDR-TB outbreak among HIV-seronegative patients in Cape Town, South Africa. Isolates were characterized by restriction fragment length polymorphism (RFLP) analysis and dot-blot hybridization analysis of mutations conferring resistance for isoniazid, rifampin, streptomycin, and ethambutol. All isolates were identical on RFLP analysis. In 2 patients, RFLP analysis showed exogenous reinfection during or after treatment for drug-susceptible TB. Mutation analysis confirmed the genotypic identity of the isolates. The infecting strain was genotypically related to strain W, which is responsible for the majority of MDR-TB outbreaks in New York City. Transmission of MDR-TB is thus not limited to HIV-seropositive patients in an institutional setting but occurs within a community.
dc.description.versionArticle
dc.identifier.citationJournal of Infectious Diseases
dc.identifier.citation180
dc.identifier.citation5
dc.identifier.issn221899
dc.identifier.other10.1086/315054
dc.identifier.urihttp://hdl.handle.net/10019.1/12681
dc.subjectethambutol
dc.subjectethionamide
dc.subjectisoniazid
dc.subjectrifampicin
dc.subjectstreptomycin
dc.subjectthioacetazone
dc.subjectadolescent
dc.subjectadult
dc.subjectarticle
dc.subjectbacterium isolate
dc.subjectchild
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease transmission
dc.subjectfemale
dc.subjectgene mutation
dc.subjectgenotype
dc.subjecthospital infection
dc.subjecthuman
dc.subjecthuman immunodeficiency virus infection
dc.subjectmale
dc.subjectmultidrug resistance
dc.subjectmycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectpriority journal
dc.subjectSouth Africa
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAntitubercular Agents
dc.subjectBlotting, Southern
dc.subjectChild
dc.subjectDisease Outbreaks
dc.subjectFemale
dc.subjectHIV Seronegativity
dc.subjectHumans
dc.subjectInstitutionalization
dc.subjectMale
dc.subjectMicrobial Sensitivity Tests
dc.subjectMiddle Aged
dc.subjectMycobacterium tuberculosis
dc.subjectPolymorphism, Restriction Fragment Length
dc.subjectSouth Africa
dc.subjectSputum
dc.subjectTuberculosis, Multidrug-Resistant
dc.titleTransmission of a multidrug-resistant Mycobacterium tuberculosis strain resembling 'strain W' among noninstitutionalized, human immunodeficiency virus-seronegative patients
dc.typeArticle
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