Effect of propranolol on the metabolism and function of the rat heart

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dc.contributor.authorBrink A.J.
dc.contributor.authorBester AndrJ.
dc.contributor.authorLochner A.
dc.date.accessioned2011-05-15T15:59:46Z
dc.date.available2011-05-15T15:59:46Z
dc.date.issued1971
dc.description.abstractThe effect of propranolol, a beta-adrenergic blocking agent, was studied on the metabolism and function of the isolated, perfused rat heart. Propranolol (20 μm) depressed the oxygen consumption, coronary flow rate, palmitate uptake and oxidation as well as the high energy phosphate contents of the perfused heart. Propranolol significantly reduced heart rate while the time to peak height of developed tension period was increased. The effect of propranolol was also studied on the metabolism of heart muscle slices and the sarcosomal oxidative phosphorylation process. With pyruvate or glucose as substrate, propranolol stimulated the respiration and metabolism of heart slices, while it depressed oxidative phosphorylation. In order to eliminate the effect of the reduction in heart rate on substrate metabolism in the perfused heart, additional studies were performed in which the effect of propranolol was studied in hearts driven at a controlled heart rate, by a pacemaker. The results showed that the chronotropic effect of propranolol had a significant effect on the reduction in substrate metabolism. © 1971.
dc.description.versionArticle
dc.identifier.citationJournal of Molecular and Cellular Cardiology
dc.identifier.citation2
dc.identifier.citation2
dc.identifier.issn222828
dc.identifier.urihttp://hdl.handle.net/10019.1/11351
dc.subjectadenine nucleotide
dc.subjectcarbon
dc.subjectcreatine phosphate
dc.subjectglucose
dc.subjectpalmitic acid derivative
dc.subjectphosphate
dc.subjectpropranolol
dc.subjectpyruvic acid derivative
dc.subjectanimal
dc.subjectarticle
dc.subjectartificial heart pacemaker
dc.subjectbiomechanics
dc.subjectchemical phenomena
dc.subjectcoronary artery blood flow
dc.subjectdrug effect
dc.subjectendoplasmic reticulum
dc.subjectfemale
dc.subjectglycolysis
dc.subjectheart
dc.subjectheart muscle
dc.subjectheart rate
dc.subjectmetabolism
dc.subjectoxidative phosphorylation
dc.subjectoxygen consumption
dc.subjectperfusion
dc.subjectphysiology
dc.subjectrat
dc.subjecttissue culture
dc.subjectAdenine Nucleotides
dc.subjectAnimal
dc.subjectBiomechanics
dc.subjectCarbon Isotopes
dc.subjectCoronary Circulation
dc.subjectDepression, Chemical
dc.subjectEndoplasmic Reticulum
dc.subjectFemale
dc.subjectGlucose
dc.subjectGlycolysis
dc.subjectHeart
dc.subjectHeart Rate
dc.subjectMyocardium
dc.subjectOxidative Phosphorylation
dc.subjectOxygen Consumption
dc.subjectPacemaker, Artificial
dc.subjectPalmitic Acids
dc.subjectPerfusion
dc.subjectPhosphates
dc.subjectPhosphocreatine
dc.subjectPropranolol
dc.subjectPyruvates
dc.subjectRats
dc.subjectTissue Culture
dc.titleEffect of propranolol on the metabolism and function of the rat heart
dc.typeArticle
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