EVAR: Critical applied aortic morphology relevant to type-II endoleaks following device enhancement in patients with abdominal aortic aneurysms

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dc.contributor.authorDu Toit D.F.
dc.contributor.authorSaaiman J.A.
dc.contributor.authorLabuschagne B.C.J.
dc.contributor.authorVorster W.
dc.contributor.authorVan Beek F.J.
dc.contributor.authorBoden B.H.
dc.contributor.authorGeldenhuys K.M.
dc.date.accessioned2011-05-15T15:56:42Z
dc.date.available2011-05-15T15:56:42Z
dc.date.issued2004
dc.description.abstractEndovascular repair (EVAR) of abdominal aortic aneurysms (AAA) is an established alternative option to conventional surgery for AAA, provided optimal anatomical morphology of the aneurysm sac, neck and outflow exists. In most documented series of EVAR, type-II endoleak occurrence is a universal procedural drawback. This is referred to as the Achilles heel of EVAR. This morphological study, addressing predominantly non-aneurysmal aortic anatomy, reveals the dyssynchronous origins of the renal ostia, ectopia of the superior mesenteric artery and median sacral artery, variations in the length of the infrarenal abdominal aorta, multiple mainstem renal arteries, and the presence of accessory renal arteries (in 13% of cadavers). Such potential vascular anomalies need careful consideration pre-operatively prior to EVAR. In a prospective, clinical study of EVAR in 163 patients over 60 months, using four different aortic stent devices, we demonstrated an intraprocedural type-II endoleak rate, before exclusion, of 3% (5/163). Most were related to patent lumbar arteries. An active policy of intraprocedural aneurysm pressure sac measurement and angiography was used to demonstrate type-I and type-II endoleaks, focusing on the applied anatomy of aortic side branches and variations. Selective intraprocedural coli embolisation and thrombin injection into the sac was utilised to thrombose persisting and large lumbar arteries that predisposed to retroleaks. We recorded a low incidence of persisting type-II endoleaks using this proactive treatment strategy by addressing variant aortic morphology and patent lumbar arteries during EVAR. One aneurysm-related death (0.6%) was observed due to late rupture after EVAR, and a single intraprocedural death was related to unpredictable aneurysm rupture. In conclusion, comprehensive anatomical knowledge of the abdominal aorta and its main collateral side branches, including variations, is a fundamental prerequisite if satisfactory and predictable results are to be achieved after EVAR, especially regarding prevention, diagnosis and treatment of type-II endoleaks. Intraprocedaral aneurysm sac pressure monitoring, coil embolisation and the use of injection of thrombin into the aneurysm sac of selected patients is useful in reducing the incidence of post-EVAR type-II persisting endoleaks.
dc.description.versionConference Paper
dc.identifier.citationCardiovascular Journal of South Africa
dc.identifier.citation15
dc.identifier.citation4
dc.identifier.issn10159657
dc.identifier.urihttp://hdl.handle.net/10019.1/9996
dc.subjectthrombin
dc.subjectabdominal aorta
dc.subjectabdominal aorta aneurysm
dc.subjectadult
dc.subjectaged
dc.subjectaneurysm rupture
dc.subjectangiography
dc.subjectartery thrombosis
dc.subjectclinical trial
dc.subjectcoil embolization
dc.subjectconference paper
dc.subjectendoleak
dc.subjectendovascular surgery
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprospective study
dc.subjectrenal artery
dc.subjectstent
dc.subjectsuperior mesenteric artery
dc.subjectvascular patency
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAngioplasty
dc.subjectAorta, Abdominal
dc.subjectAortic Aneurysm, Abdominal
dc.subjectBlood Vessel Prosthesis
dc.subjectBlood Vessel Prosthesis Implantation
dc.subjectCadaver
dc.subjectFemale
dc.subjectHumans
dc.subjectIncidence
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPostoperative Complications
dc.subjectProspective Studies
dc.subjectProsthesis Failure
dc.subjectTreatment Outcome
dc.titleEVAR: Critical applied aortic morphology relevant to type-II endoleaks following device enhancement in patients with abdominal aortic aneurysms
dc.typeConference Paper
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