Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia

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dc.contributor.advisorGlashoff, Richard H.en_ZA
dc.contributor.advisorIpp, Hayleyen_ZA
dc.contributor.authorLoots, Stanleyen_ZA
dc.contributor.otherStellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology, Medical Virology.en_ZA
dc.date.accessioned2013-11-28T05:27:35Zen_ZA
dc.date.accessioned2013-12-13T17:10:53Z
dc.date.available2013-11-28T05:27:35Zen_ZA
dc.date.available2013-12-13T17:10:53Z
dc.date.issued2013-12en_ZA
dc.descriptionThesis (MScMedSc)-- Stellenbosch University, 2013.en_ZA
dc.description.abstractENGLISH ABSTRACT: Chronic HIV-1 infection is characterized by extensive inflammation/immune activation and also by anaemia. Macrophages and neutrophils produce reactive oxygen species (ROS) which can cause damage to surrounding cells, including erythrocytes. Damaged erythrocytes may die by apoptosis (erythroptosis) or be tagged for clearance by monocytes/ macrophages. In this study we investigated HIV-1-associated anaemia and erythroptosis in asymptomatic, untreated HIV-1 infected individuals and how it relates to oxidative stress and immune activation.en_ZA
dc.description.abstractAFRIKAANSE OPSOMMING: Chroniese MIV-1 infeksie word gekenmerk deur uitgebreide inflammasie/immuun aktivering en ook deur anemie. Makrofage en neutrofiele produseer reaktiewe suurstof spesies (ROS), wat kan skade aan omliggende selle, insluitend rooibloedselle veroorsaak. Beskadigde rooibloedselle kan sterf deur apoptose (erythroptosis) of gemerk vir klaring deur monosiete/makrofage. In hierdie studie het ons ondersoek MIV-1-verwante bloedarmoede en erythroptosis in asimptomatiese, onbehandelde MIV-1 besmette individue en hoe dit verband hou met oksidatiewe stres en immuun aktivering.af_ZA
dc.description.sponsorshipThe Poliomyelitis Research Foundation (PRFen_ZA
dc.format.extentxx, 89 p. : col. ill.
dc.identifier.urihttp://hdl.handle.net/10019.1/85803
dc.language.isoen_ZA
dc.publisherStellenbosch : Stellenbosch Universityen_ZA
dc.rights.holderStellenbosch Universityen_ZA
dc.subjectErythrocyte apoptosis anaemia HIVen_ZA
dc.subjectAnaemia in chronic HIV-positive personsen_ZA
dc.subjectTheses -- Medicineen_ZA
dc.subjectDissertations -- Medicineen_ZA
dc.subjectTheses -- Medical virologyen_ZA
dc.subjectDissertations -- Medical virologyen_ZA
dc.subjectHIV (Viruses)en_ZA
dc.subjectCell deathen_ZA
dc.subjectApoptosisen_ZA
dc.subjectHIV positive persons -- Anaemiaen_ZA
dc.titleErythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemiaen_ZA
dc.typeThesisen_ZA
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