Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to the pas system of pTF-FC2

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dc.contributor.authorRawlings D.E.
dc.date.accessioned2011-05-15T16:04:57Z
dc.date.available2011-05-15T16:04:57Z
dc.date.issued1999
dc.description.abstractGenes encoding toxin-antitoxin proteins are frequently found on plasmids where they serve to stabilize the plasmid within a bacterial population. The toxin-antitoxin proteins do not increase the likelihood of a progeny cell receiving a plasmid but rather function as post-segregational killing mechanisms which decrease the proportion of cells that survive after losing the plasmid. These toxin-antitoxin couples therefore act as plasmid addiction systems. Several new proteic toxin-antitoxin systems have been identified and these systems appear to be ubiquitous on the chromosomes of bacteria and archaea. When placed on plasmids, these chromosomal systems also have the ability to stabilize plasmids and in at least one case, chromosomal- and plasmid-based toxin-antitoxin systems have been shown to interact. Recent findings regarding toxin-antitoxin systems and questions that have arisen as a result of these findings are reviewed. Copyright (C) 1999 Federation of European Microbiological Societies.
dc.description.versionReview
dc.identifier.citationFEMS Microbiology Letters
dc.identifier.citation176
dc.identifier.citation2
dc.identifier.issn3781097
dc.identifier.other10.1016/S0378-1097(99)00256-6
dc.identifier.urihttp://hdl.handle.net/10019.1/12903
dc.subjectantitoxin
dc.subjectcomplementary RNA
dc.subjectprotein
dc.subjectRNA
dc.subjecttoxin
dc.subjectarchaebacterium
dc.subjectautoregulation
dc.subjectbacterial gene
dc.subjectbacterium
dc.subjectchromosome
dc.subjectevolution
dc.subjectnonhuman
dc.subjectoperon
dc.subjectplasmid
dc.subjectpriority journal
dc.subjectreview
dc.subjectBacterial Proteins
dc.subjectBacterial Toxins
dc.subjectChromosome Mapping
dc.subjectChromosomes, Bacterial
dc.subjectEscherichia coli
dc.subjectEvolution, Molecular
dc.subjectGene Expression Regulation, Bacterial
dc.subjectOperon
dc.subjectPlasmids
dc.subjectRNA, Antisense
dc.subjectRNA, Bacterial
dc.subjectSpecies Specificity
dc.subjectThiobacillus
dc.subjectArchaea
dc.subjectBacteria (microorganisms)
dc.titleProteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution with special reference to the pas system of pTF-FC2
dc.typeReview
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