Combination antiretroviral treatment use in prevention of mother-to-child transmission programmes : 6-week HIV prevalence and relationship to time of antiretroviral treatment initiation and mixed feeding

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dc.contributor.authorNdarukwa, Victoriaen_ZA
dc.contributor.authorZunza, Moleenen_ZA
dc.date.accessioned2021-08-26T08:52:56Z
dc.date.available2021-08-26T08:52:56Z
dc.date.issued2019
dc.descriptionCITATION: Ndarukwa, V. & Zunza, M. 2019. Combination antiretroviral treatment use in prevention of mother-to-child transmission programmes : 6-week HIV prevalence and relationship to time of antiretroviral treatment initiation and mixed feeding. Southern African Journal of Infectious Diseases, 34(1):a117, doi:10.4102/sajid.v34i1.117.
dc.descriptionThe original publication is available at https://sajid.co.za
dc.description.abstractBackground: In Zimbabwe, 16% of pregnant women aged 15–49 years are infected with HIV. More than 90% of HIV infection in children is through mother-to-child transmission (MTCT). We investigated the effectiveness of the Option B+ in reducing HIV infection and factors associated with HIV transmission among infants born to mothers enrolled in the prevention of mother-to-child transmission (PMTCT) programme. Methods: We randomly selected 1204 early infant HIV diagnosis test results for HIV-exposed infants and linked these results to maternal clinical records at primary healthcare clinics in Harare to estimate the prevalence of MTCT and to determine the clinical factors associated with MTCT of HIV at 6 weeks. Results: Of the 1204 infants in the study, 2.5% (95% confidence interval [CI], 1.7–3.5) were infected with HIV at 6 weeks post-delivery. Antiretroviral adherence reduced the odds of HIV infection by about 99% (odds ratio [OR] 0.01 [95% CI, 0.00–0.06]). Both mixed feeding (OR 3.89 [95% CI, 0.92–16.50]) and late initiation of antiretroviral treatment (ART) (after delivery) (OR 3.18 [95% CI, 0.42–23.94]) increased the odds of HIV infection. Conclusion: Early initiation of combination ART reduces 6-week MTCT of HIV in PMTCT programmes to levels similar to those found in controlled trial settings. Exclusive breastfeeding remains important even in the presence of ART.en_ZA
dc.description.urihttps://sajid.co.za/index.php/sajid/article/view/117
dc.description.versionPublisher's version
dc.format.extent5 pagesen_ZA
dc.identifier.citationNdarukwa, V. & Zunza, M. 2019. Combination antiretroviral treatment use in prevention of mother-to-child transmission programmes : 6-week HIV prevalence and relationship to time of antiretroviral treatment initiation and mixed feeding. Southern African Journal of Infectious Diseases, 34(1):a117, doi:10.4102/sajid.v34i1.117
dc.identifier.issn2313-1810 (online)
dc.identifier.issn2312-0053 (print)
dc.identifier.otherdoi:10.4102/sajid.v34i1.117
dc.identifier.urihttp://hdl.handle.net/10019.1/117161
dc.language.isoen_ZAen_ZA
dc.publisherAOSISen_ZA
dc.rights.holderAuthors retain copyrighten_ZA
dc.subjectHIV/AIDSen_ZA
dc.subjectAntiretroviral agentsen_ZA
dc.subjectHIV infections -- Preventionen_ZA
dc.subjectBreastfeedingen_ZA
dc.titleCombination antiretroviral treatment use in prevention of mother-to-child transmission programmes : 6-week HIV prevalence and relationship to time of antiretroviral treatment initiation and mixed feedingen_ZA
dc.typeArticleen_ZA
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