Normothermic ischaemic cardiac arrest and reperfusion of the isolated working heart: Effect of chlorpromazine on functional, metabolic and morphological recovery

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dc.contributor.authorEdoute Y.
dc.contributor.authorVan der Merwe E.L.
dc.contributor.authorSanan D.
dc.date.accessioned2011-05-15T15:59:44Z
dc.date.available2011-05-15T15:59:44Z
dc.date.issued1983
dc.description.abstractThe effects of chlorpromazine, an inhibitor of both Ca2+ flux and phospholipase activity, on myocardial ultrastructure, function and metabolism were assessed during normothermic ischaemic cardiac arrest and reperfusion of the isolated working rat heart. Normothermic ischaemic cardiac arrest produced significant changes in myocardial ultrastructure, high energy phosphate contents and mitochondrial oxidative phosphorylation within 20 min. Reperfusion of untreated hearts subjected to 20 and 25 min ischaemia failed to restore mitochondrial function, mechanical activity and ATP contents to control, pre-ischaemic levels. Morphological signs of ischaemic injury regressed, especially in the subendocardial layer. Pretreatment of hearts with chlorpromazine did not prevent the ischaemia-induced changes in myocardial ultrastructure and mitochondrial function. However, during reperfusion the chlorpromazine-treated, totally ischaemic hearts (20 to 25 min) exhibited improved coronary flow rates, and ultrastructural and mechanical recovery. The mitochondrial oxidative phosphorylation process and tissue high energy phosphate contents were not affected by the drug.
dc.description.versionArticle
dc.identifier.citationJournal of Molecular and Cellular Cardiology
dc.identifier.citation15
dc.identifier.citation9
dc.identifier.issn222828
dc.identifier.urihttp://hdl.handle.net/10019.1/11334
dc.subjectchlorpromazine
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectelectron microscopy
dc.subjectheart
dc.subjectheart arrest
dc.subjectheart function
dc.subjectheart muscle ischemia
dc.subjectheart muscle metabolism
dc.subjectisolated heart
dc.subjectnonhuman
dc.subjectrat
dc.subjectultrastructure
dc.subjectAdenosine Triphosphate
dc.subjectAnimal
dc.subjectChlorpromazine
dc.subjectHeart
dc.subjectHeart Arrest, Induced
dc.subjectMale
dc.subjectMitochondria, Heart
dc.subjectMyocardium
dc.subjectOxidative Phosphorylation
dc.subjectPerfusion
dc.subjectPhosphocreatine
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.titleNormothermic ischaemic cardiac arrest and reperfusion of the isolated working heart: Effect of chlorpromazine on functional, metabolic and morphological recovery
dc.typeArticle
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