Permeability of intestinal mucosa to crystalline and tabletted isoniazid (INH)
Date
2003
Journal Title
Journal ISSN
Volume Title
Publisher
Health & Medical Publishing Group
Abstract
When administered orally, isoniazid (INH),
which continues to form the basis of most first-line standard
antituberculosis regimens, reaches peak plasma concentrations
of 3 - 5 μg/ml within 1 - 2 hours after ingestion of usual doses.1
Various tablet and slow-release matrix forms are available and
these processed preparations are most often used clinically.
However, various studies undertaken in our Department have
shown crystalline INH to produce better blood levels within
the first 2 hours after ingestion than the commonly used
tabletted form.
Description
CITATION: Van der Bijl, P., Seifart, H. I. & Van Eyk, A. D. 2003. Permeability of intestinal mucosa to crystalline and tabletted isoniazid (INH). South African Medical Journal, 93(2):127-128.
The original publication is available at http://www.samj.org.za
The original publication is available at http://www.samj.org.za
Keywords
Isoniazid