Comparison of various physiologic and psychomotor parameters in patients sedated with intravenous lorazepam, diazepam, or midazolam during oral surgery

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dc.contributor.authorVan der Bijl P.
dc.contributor.authorRoelofse J.A.
dc.contributor.authorDe Joubert V.J.J.
dc.contributor.authorVan Zyl J.F.
dc.date.accessioned2011-05-15T16:02:01Z
dc.date.available2011-05-15T16:02:01Z
dc.date.issued1991
dc.description.abstractIntravenously administered lorazepam (0.05 mg/kg), diazepam (0.25 mg/kg), and midazolam (0.1 mg/kg) were compared for sedation during oral surgery under local anesthesia. Sixty patients were randomly allocated into three groups in this double-blind, parallel study. The results from this trial show that all three drugs provide satisfactory sedation. Average mean arterial pressures, however, decreased significantly with midazolam and diazepam. Statistically significantly higher heart rates during the entire procedure were also found for lorazepam when compared with diazepam and midazolam. At the postblock stage, the midazolam group had respiratory rates that were significantly higher than those of the other two drug groups. Patients in the diazepam and midazolam groups took significantly longer to complete the pegboard test at the preblock stage than those in the lorazepam group. At 1, 1.5, and 2 hours after arrival in the recovery room, an inversion of groups took place, with the lorazepam group taking significantly longer for their tests than the other two groups. Significantly more improvement in anxiety levels was found at 10 minutes postdrug for the patients who had received diazepam and this tended to remain so on arrival in the recovery room. When compared with the other two groups, significantly more patients in the lorazepam group reported giddiness/dizziness and significantly more in the diazepam group reported pain on injection.
dc.description.versionArticle
dc.identifier.citationJournal of Oral and Maxillofacial Surgery
dc.identifier.citation49
dc.identifier.citation7
dc.identifier.issn2782391
dc.identifier.urihttp://hdl.handle.net/10019.1/12271
dc.subjectdiazepam
dc.subjectlorazepam
dc.subjectmidazolam
dc.subjectsedative agent
dc.subjectadult
dc.subjectanesthesia
dc.subjectarticle
dc.subjectcontrolled study
dc.subjectdental surgery
dc.subjectdrug therapy
dc.subjectfemale
dc.subjecthuman
dc.subjectintravenous drug administration
dc.subjectlocal anesthesia
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoral surgery
dc.subjectpriority journal
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectAnesthesia, Dental
dc.subjectAnesthesia, Local
dc.subjectAnxiety
dc.subjectBlood Pressure
dc.subjectComparative Study
dc.subjectConscious Sedation
dc.subjectDiazepam
dc.subjectFemale
dc.subjectHeart Rate
dc.subjectHuman
dc.subjectLorazepam
dc.subjectMale
dc.subjectMidazolam
dc.subjectMolar, Third
dc.subjectRespiration
dc.subjectSurgery, Oral
dc.subjectTooth Extraction
dc.titleComparison of various physiologic and psychomotor parameters in patients sedated with intravenous lorazepam, diazepam, or midazolam during oral surgery
dc.typeArticle
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