Erythrocyte membrane fatty acids in patients with multiple sclerosis

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dc.contributor.authorHon, G. M.
dc.contributor.authorHassan, M. S.
dc.contributor.authorVan Rensburg, S. J.
dc.contributor.authorAbel, S.
dc.contributor.authorMarais, D. W.
dc.contributor.authorVan Jaarsveld, P.
dc.contributor.authorSmuts, C. M.
dc.contributor.authorHenning, F.
dc.contributor.authorErasmus, R. T.
dc.contributor.authorMatsha, T.
dc.date.accessioned2011-05-15T16:17:25Z
dc.date.available2011-05-15T16:17:25Z
dc.date.issued2009
dc.description.abstractBackground: Reports on fatty acids levels in multiple sclerosis remain inconclusive. Objective: To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale. Methods: Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography. Results: The membrane phosphatidylcholine C20:4 n-6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS. Conclusion: Decrease in C20:4 n-6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.
dc.description.versionArticle
dc.identifier.citationMultiple Sclerosis
dc.identifier.citation15
dc.identifier.citation6
dc.identifier.issn13524585
dc.identifier.other10.1177/1352458509103321
dc.identifier.urihttp://hdl.handle.net/10019.1/14207
dc.subjectfatty acid derivative
dc.subjectimmunosuppressive agent
dc.subjectnonsteroid antiinflammatory agent
dc.subjectphosphatidylcholine
dc.subjectarticle
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdisease severity
dc.subjecterythrocyte membrane
dc.subjectExpanded Disability Status Scale
dc.subjectfemale
dc.subjectgas chromatography
dc.subjecthuman
dc.subjectindividuality
dc.subjectlipid composition
dc.subjectmultiple sclerosis
dc.subjectprotein depletion
dc.subjectscoring system
dc.subjectChromatography, Gas
dc.subjectDisability Evaluation
dc.subjectErythrocyte Membrane
dc.subjectFatty Acids
dc.subjectFemale
dc.subjectHumans
dc.subjectMultiple Sclerosis, Chronic Progressive
dc.subjectMultiple Sclerosis, Relapsing-Remitting
dc.subjectPhosphatidylcholines
dc.subjectSeverity of Illness Index
dc.titleErythrocyte membrane fatty acids in patients with multiple sclerosis
dc.typeArticle
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