Erythrocyte membrane fatty acids in patients with multiple sclerosis

Hon, G. M.
Hassan, M. S.
Van Rensburg, S. J.
Abel, S.
Marais, D. W.
Van Jaarsveld, P.
Smuts, C. M.
Henning, F.
Erasmus, R. T.
Matsha, T.
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Background: Reports on fatty acids levels in multiple sclerosis remain inconclusive. Objective: To determine the erythrocyte membrane fatty acid levels in multiple sclerosis patients and correlate with Kurtzke Expanded Disability Status Scale. Methods: Fatty acid composition of 31 multiple sclerosis and 30 control individuals were measured by gas chromatography. Results: The membrane phosphatidylcholine C20:4 n-6 concentration was lower in the multiple sclerosis patients when compared to that of the control group, P = 0.04 and it correlated inversely with the EDSS and FSS. Conclusion: Decrease in C20:4 n-6 in the erythrocyte membrane could be an indication of depleted plasma stores, and a reflection of disease severity.
fatty acid derivative, immunosuppressive agent, nonsteroid antiinflammatory agent, phosphatidylcholine, article, clinical article, controlled study, correlation analysis, disease severity, erythrocyte membrane, Expanded Disability Status Scale, female, gas chromatography, human, individuality, lipid composition, multiple sclerosis, protein depletion, scoring system, Chromatography, Gas, Disability Evaluation, Erythrocyte Membrane, Fatty Acids, Female, Humans, Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Relapsing-Remitting, Phosphatidylcholines, Severity of Illness Index
Multiple Sclerosis