Inositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive - compulsive disorder: An open trial

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dc.contributor.authorSeedat S.
dc.contributor.authorStein D.J.
dc.date.accessioned2011-05-15T15:59:19Z
dc.date.available2011-05-15T15:59:19Z
dc.date.issued1999
dc.description.abstractInositol, an isomer of glucose and precursor in the phosphatidylinositol cycle, may be effective in a number of psychiatric disorders, including obsessive - compulsive disorder (OCD). There is little data, however, on inositol as an augmenting agent of serotonin reuptake inhibitors (SRIs) in treatment-refractory patients. Ten OCD patients who had failed to respond to current and previous trials of serotonin reuptake inhibitors participated in open-label trial of inositol (18 mg/day) augmentation for 6 weeks. Symptoms were rated at 2-weekly intervals using the Yale-Brown Obsessive - Compulsive Scale, the Montgomery - Asberg Depression Rating Scale, and the Clinical Global Impressions (CGI) Scale. The majority of patients (n = 7) did not respond to treatment with inositol augmentation on the CGI improvement item. However, a small number of patients (n = 3) did report a clinically significant response on the CGI improvement item. OCD patients who fail to respond to a number of trials of SRIs may be a particularly treatment-refractory group of subjects. Unfortunately, inositol augmentation of a SRI did not lead to significant improvement in the majority of such cases. Nevertheless, further research on the mechanism of inositol efficacy in some patients with anxiety and mood disorders is warranted.
dc.description.versionArticle
dc.identifier.citationInternational Clinical Psychopharmacology
dc.identifier.citation14
dc.identifier.citation6
dc.identifier.issn2681315
dc.identifier.other10.1097/00004850-199911000-00005
dc.identifier.urihttp://hdl.handle.net/10019.1/11114
dc.subjectclomipramine
dc.subjectfluoxetine
dc.subjectinositol
dc.subjectphosphatidylinositol
dc.subjectserotonin uptake inhibitor
dc.subjectsertraline
dc.subjectabdominal pain
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdiarrhea
dc.subjectfemale
dc.subjectflatulence
dc.subjecthuman
dc.subjectmale
dc.subjectnausea
dc.subjectobsession
dc.subjectpriority journal
dc.subjectrating scale
dc.subjectside effect
dc.subjectsymptom
dc.subjectAdolescent
dc.subjectAdult
dc.subjectDrug Therapy, Combination
dc.subjectFemale
dc.subjectHumans
dc.subjectInositol
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectObsessive-Compulsive Disorder
dc.subjectPsychiatric Status Rating Scales
dc.subjectSerotonin Uptake Inhibitors
dc.titleInositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive - compulsive disorder: An open trial
dc.typeArticle
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