Rat brain monoamine and serotonin S2 receptor changes during pregnancy

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dc.contributor.authorGlaser J.
dc.contributor.authorRussell V.A.
dc.contributor.authorDe Villiers A.S.
dc.contributor.authorSearson J.A.
dc.contributor.authorTaljaard J.J.F.
dc.date.accessioned2011-05-15T16:17:27Z
dc.date.available2011-05-15T16:17:27Z
dc.date.issued1990
dc.description.abstractThe concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decrease in striatal and frontal cortex 5-hydroxyindole-3-acetic acid (5-HIAA) concentration was observed in 15 day pregnant rats. Significant increases in hypothalamic and hippocampal NA levels were observed at 4 days post-partum. Frontal cortex serotonin S2 receptor KD was reduced in 4 day post-partum rats. There was no significant change in S2 receptor B(max) during pregnancy. Levels of progesterone were negatively correlated with striatal DA, homovanillic acid (HVA), 5-HT, and 5-HIAA levels, hypothalamic DA, hippocampal 5-HT, and frontal cortex 5-HIAA values as well as striatal HVA to DA, and HVA to 3,4-dihydroxyphenylacetic acid (DOPAC) ratios and amygdaloid HVA to DOPAC ratios. The limbic neurotransmitter changes might possibly contribute to mood changes which occur during pregnancy and post-partum.
dc.description.versionArticle
dc.identifier.citationNeurochemical Research
dc.identifier.citation15
dc.identifier.citation10
dc.identifier.issn03643190
dc.identifier.other10.1007/BF00965738
dc.identifier.urihttp://hdl.handle.net/10019.1/14225
dc.subjectcorticosterone
dc.subjectdopamine
dc.subjectestradiol
dc.subjectmonoamine
dc.subjectnoradrenalin
dc.subjectprogesterone
dc.subjectserotonin
dc.subjectserotonin 2 receptor
dc.subjectanimal tissue
dc.subjectarticle
dc.subjectbrain level
dc.subjectbrain region
dc.subjectfemale
dc.subjectlimbic system
dc.subjectnonhuman
dc.subjectpregnancy
dc.subjectpriority journal
dc.subjectrat
dc.subject3,4-Dihydroxyphenylacetic Acid
dc.subjectAnimal
dc.subjectBiogenic Amines
dc.subjectBrain
dc.subjectCorticosterone
dc.subjectDopamine
dc.subjectEstradiol
dc.subjectEstrus
dc.subjectFemale
dc.subjectHomovanillic Acid
dc.subjectNorepinephrine
dc.subjectOrgan Specificity
dc.subjectPregnancy
dc.subjectPregnancy, Animal
dc.subjectProgesterone
dc.subjectPuerperium
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReceptors, Serotonin
dc.subjectSerotonin
dc.subjectSupport, Non-U.S. Gov't
dc.subjectAnimalia
dc.titleRat brain monoamine and serotonin S2 receptor changes during pregnancy
dc.typeArticle
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