Rat brain monoamine and serotonin S2 receptor changes during pregnancy
Date
1990
Authors
Glaser J.
Russell V.A.
De Villiers A.S.
Searson J.A.
Taljaard J.J.F.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT), and their metabolites were determined in 5 brain areas of non-pregnant, 15 and 20 day pregnant and 4 day post-partum rats. Striatal 5-HT content was significantly lower in 15 and 20 day pregnant rats than in estrous controls. A significant decrease in striatal and frontal cortex 5-hydroxyindole-3-acetic acid (5-HIAA) concentration was observed in 15 day pregnant rats. Significant increases in hypothalamic and hippocampal NA levels were observed at 4 days post-partum. Frontal cortex serotonin S2 receptor KD was reduced in 4 day post-partum rats. There was no significant change in S2 receptor B(max) during pregnancy. Levels of progesterone were negatively correlated with striatal DA, homovanillic acid (HVA), 5-HT, and 5-HIAA levels, hypothalamic DA, hippocampal 5-HT, and frontal cortex 5-HIAA values as well as striatal HVA to DA, and HVA to 3,4-dihydroxyphenylacetic acid (DOPAC) ratios and amygdaloid HVA to DOPAC ratios. The limbic neurotransmitter changes might possibly contribute to mood changes which occur during pregnancy and post-partum.
Description
Keywords
corticosterone, dopamine, estradiol, monoamine, noradrenalin, progesterone, serotonin, serotonin 2 receptor, animal tissue, article, brain level, brain region, female, limbic system, nonhuman, pregnancy, priority journal, rat, 3,4-Dihydroxyphenylacetic Acid, Animal, Biogenic Amines, Brain, Corticosterone, Dopamine, Estradiol, Estrus, Female, Homovanillic Acid, Norepinephrine, Organ Specificity, Pregnancy, Pregnancy, Animal, Progesterone, Puerperium, Rats, Rats, Inbred Strains, Receptors, Serotonin, Serotonin, Support, Non-U.S. Gov't, Animalia
Citation
Neurochemical Research
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